Evidence map›Paper›PMID 24836413›Full record

ArticleJournal of medical microbiology2014

Characterization of culturable vaginal Lactobacillus species among women with and without bacterial vaginosis from the United States and India: a cross-sectional study.

Purnima Madhivanan, Eva Raphael, Alnecia Rumphs, Karl Krupp, Kavitha Ravi, Vijaya Srinivas, Anjali Arun, Arthur L Reingold, Jeffrey D Klausner, Lee W Riley

Abstract read
In one paragraph

Article in Journal of medical microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Clustering Analysis of the Multi-Microbial Consortium byFrontiers in cellular and infection microbiology · 2022
    Article
  7. Limitations of 16S rRNA Gene Sequencing to CharacterizeFrontiers in cell and developmental biology · 2021
    Article
  8. Article
  9. Article
  10. Identification and Sensitivity of Vaginal and ProbioticJournal of laboratory physicians · 2020
    Article
  11. Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Purnima MadhivananPublic Health Research Institute of India, Mysore, India.
Eva RaphaelEmory University School of Medicine, Atlanta, GA, USA.
Alnecia RumphsRobert Stempel College of Public Health and Social Work, Florida International University, Miami, FL, USA.
Karl KruppPublic Health Research Institute of India, Mysore, India.
Kavitha RaviPublic Health Research Institute of India, Mysore, India.
Vijaya SrinivasPublic Health Research Institute of India, Mysore, India.
Anjali ArunPublic Health Research Institute of India, Mysore, India.
Arthur L ReingoldDivision of Epidemiology, School of Public Health, University of California, Berkeley, CA, USA.
Jeffrey D KlausnerDivision of Infectious Diseases, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Lee W RileyDivision of Epidemiology, School of Public Health, University of California, Berkeley, CA, USA.

Funding

UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
UCLA Rapid, Relevant, Rigorous Implementation Science HubP30MH058107 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI RAPHAEL J LANDOVITZ · 1997 to 2026
$53.5M
Virology CoreP30AI028697 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ANTON, PETER A · 1991 to 2018
$39.9M
Joint U.S.-India Study of Lactobacillus and its Phages in Bacterial VaginosisR03HD055117 · NICHD · UNIVERSITY OF CALIFORNIA BERKELEY · PI REINGOLD, ARTHUR L · 2007 to 2008
$137k
NCATS NIH HHS UL1 TR000124NIAID NIH HHS P30 AI028697NICHD NIH HHS 5R03HD055117-02NICHD NIH HHS R03 HD055117NIMH NIH HHS P30 MH058107
6 · The paper itself

Abstract

Lactobacillus species play an integral part in the health of the vaginal microbiota. We compared vaginal Lactobacillus species in women from India and the USA with and without bacterial vaginosis (BV). Between July 2009 and November 2010, a cross-sectional study was conducted among 40 women attending a women's health clinic in Mysore, India, and a sexually transmitted diseases clinic in San Francisco, USA. Women were diagnosed with BV using Amsel's criteria and the Nugent score. Lactobacillus 16S rDNA was sequenced to speciate the cultured isolates. Ten Indian and 10 US women without BV were compared with an equal number of women with BV. Lactobacilli were isolated from all healthy women, but from only 10% of Indian and 50% of US women with BV. 16S rDNA from 164 Lactobacillus colonies was sequenced from healthy women (126 colonies) and women with BV (38 colonies). Seven cultivable Lactobacillus species were isolated from 11 Indian women and nine species from 15 US women. The majority of Lactobacillus species among Indian women were L. crispatus (25.0%), L. jensenii (25.0%) and L. reuteri (16.7%). Among US women, L. crispatus (32.0%), L. jensenii (20.0%) and L. coleohominis (12.0%) predominated. L. jensenii and L. crispatus dominated the vaginal flora of healthy Indian and US women. Indian women appeared to have a higher percentage of obligate heterofermentative species, suggesting the need for a larger degree of metabolic flexibility and a more challenging vaginal environment.

Indexed as

AdolescentAdultCross-Sectional StudiesFemaleHumansIndiaLactobacillusSan FranciscoVaginosis, BacterialYoung Adult

Identifiers

PMID24836413
PMCPMC4064353

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.