SynthesisNature genetics2014
Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk.
Open access · greenAbstract readMeta-Analysis
In one paragraph
Synthesis in Nature genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 165 papers, 18 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
165citing papers in PubMed, 18 pooled it
21.7field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
165 citing papers in PubMed, 18 syntheses or guidelines pooled it, 243 citations in OpenAlex.
- Developing and validating polygenic risk scores for colorectal cancer risk prediction in East Asians.International journal of cancer · 2022Pooled it
- Large-scale Integrated Analysis of Genetics and Metabolomic Data Reveals Potential Links Between Lipids and Colorectal Cancer Risk.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2022Pooled it
- Genome-wide association meta-analysis identifies GP2 gene risk variants for pancreatic cancer.Nature communications · 2020Pooled it
- Genome-wide association study of INDELs identified four novel susceptibility loci associated with lung cancer risk.International journal of cancer · 2020Pooled it
- Identification of novel breast cancer susceptibility loci in meta-analyses conducted among Asian and European descendants.Nature communications · 2020Pooled it
- Large-Scale Genome-Wide Association Study of East Asians Identifies Loci Associated With Risk for Colorectal Cancer.Gastroenterology · 2019Pooled it
- Discovery of common and rare genetic risk variants for colorectal cancer.Nature genetics · 2019Pooled it
- Combination of 247 Genome-Wide Association Studies Reveals High Cancer Risk as a Result of Evolutionary Adaptation.Molecular biology and evolution · 2018Pooled it
- Metabolome-wide association study identified the association between a circulating polyunsaturated fatty acids variant rs174548 and lung cancer.Carcinogenesis · 2017Pooled it
- SMAD7 rs4939827 variant contributes to colorectal cancer risk in Chinese population.Oncotarget · 2017Pooled it
- Pooled it
- A comprehensive meta-analysis of genetic associations between five key SNPs and colorectal cancer risk.Oncotarget · 2016Pooled it
- Pooled it
- Analyses of 7,635 Patients with Colorectal Cancer Using Independent Training and Validation Cohorts Show That rs9929218 in CDH1 Is a Prognostic Marker of Survival.Clinical cancer research : an official journal of the American Association for Cancer Research · 2015Pooled it
- Genome-wide association study of colorectal cancer identifies six new susceptibility loci.Nature communications · 2015Pooled it
- Common genetic variants (rs4779584 and rs10318) at 15q13.3 contributes to colorectal adenoma and colorectal cancer susceptibility: evidence based on 22 studies.Molecular genetics and genomics : MGG · 2015Pooled it
- A new GWAS and meta-analysis with 1000Genomes imputation identifies novel risk variants for colorectal cancer.Scientific reports · 2015Pooled it
- Quantitative assessment of the influence of common variation rs16892766 at 8q23.3 with colorectal adenoma and cancer susceptibility.Molecular genetics and genomics : MGG · 2015Pooled it
- Effects of fish oil supplementation on eicosanoid production in patients at higher risk for colorectal cancer.European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) · 2019Trial
- Colorectal Polyp Occurrence Associated With the ZMIZ1-AS1 rs704017 Variant and Hypertension Among Taiwan Biobank Participants.Cancer medicine · 2026Article
105 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
48 authors at 14 institutions in 5 countries.
Ben ZhangDivision of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Wei-Hua JiaState Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-sen University, Guangzhou, China.
Koichi MatsudaLaboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.ORCID 0000000172922686
Sun-Seog Kweon1] Department of Preventive Medicine, Chonnam National University Medical School, Gwangju, South Korea. [2] Jeonnam Regional Cancer Center, Chonnam National University Hwasun Hospital, Hwasun, South Korea.
Keitaro MatsuoDepartment of Preventive Medicine, Kyushu University Faculty of Medical Sciences, Fukuoka, Japan.
Yong-Bing XiangDepartment of Epidemiology, Shanghai Cancer Institute, Shanghai, China.
Aesun Shin1] Molecular Epidemiology Branch, National Cancer Center, Goyang-si, South Korea. [2] Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, South Korea.
Sun Ha JeeDepartment of Epidemiology and Health Promotion, Institute for Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, South Korea.
Dong-Hyun KimDepartment of Social and Preventive Medicine, Hallym University College of Medicine, Okcheon-dong, South Korea.
Qiuyin CaiDivision of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Jirong LongDivision of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Jiajun ShiDivision of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.ORCID 0000000151940009
Wanqing WenDivision of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Gong YangDivision of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Yanfeng ZhangDivision of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Chun LiDepartment of Biostatistics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Bingshan LiDepartment of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Yan GuoDepartment of Cancer Biology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Zefang RenSchool of Public Health, Sun Yat-sen University, Guangzhou, China.
Bu-Tian JiDivision of Cancer Epidemiology & Genetics, National Cancer Institute, Bethesda, Maryland, USA.
Zhi-Zhong PanState Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-sen University, Guangzhou, China.
Atsushi TakahashiCenter for Integrative Medical Sciences, RIKEN, Kanagawa, Japan.
Min-Ho ShinDepartment of Preventive Medicine, Chonnam National University Medical School, Gwangju, South Korea.
Fumihiko MatsudaCenter for Genomic Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Yu-Tang GaoDepartment of Epidemiology, Shanghai Cancer Institute, Shanghai, China.
Jae Hwan OhCenter for Colorectal Cancer, National Cancer Center, Goyang-si, South Korea.
Soriul KimDepartment of Epidemiology and Health Promotion, Institute for Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, South Korea.
Yoon-Ok AhnDepartment of Preventive Medicine, Seoul National University College of Medicine, Seoul, South Korea.
Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO)
Andrew T Chan1] Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA. [2] Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Jenny Chang-ClaudeDivision of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany.
Martha L SlatteryDepartment of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, Utah, USA.
Colorectal Transdisciplinary (CORECT) Study
Stephen B GruberUniversity of Southern California Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA.
Fredrick R SchumacherUniversity of Southern California Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA.
Stephanie L StenzelUniversity of Southern California Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA.
Colon Cancer Family Registry (CCFR)
Graham CaseyUniversity of Southern California Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA.
Hyeong-Rok KimDepartment of Surgery, Chonnam National University Medical School, Gwangju, South Korea.
Jin-Young JeongDepartment of Social and Preventive Medicine, Hallym University College of Medicine, Okcheon-dong, South Korea.
Ji Won Park1] Center for Colorectal Cancer, National Cancer Center, Goyang-si, South Korea. [2] Department of Surgery, Seoul National University Hospital, Seoul, South Korea.
Hong-Lan LiDepartment of Epidemiology, Shanghai Cancer Institute, Shanghai, China.
Satoyo HosonoDepartment of Preventive Medicine, Kyushu University Faculty of Medical Sciences, Fukuoka, Japan.
Sang-Hee ChoDepartment of Hemato-oncology, Chonnam National University Medical School, Gwangju, South Korea.
Michiaki KuboCenter for Integrative Medical Sciences, RIKEN, Kanagawa, Japan.
Xiao-Ou ShuDivision of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Yi-Xin ZengState Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-sen University, Guangzhou, China.
Wei ZhengDivision of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Vanderbilt University · USSun Yat-sen University · CNUniversity of Southern California · USKyushu University · JPChonnam National University Hospital · KRHallym University · KRYonsei University · KRKyoto University · JPSeoul National University · KRBrigham and Women's Hospital · USHarvard University · USNational Cancer Institute · USShanghai Cancer Institute · CNThe University of Tokyo · JP
Funding
USC/NORRIS COMPREHENSIVE CANCER CENTER (CORE) SUPPORTP30CA014089 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MYLES G COCKBURN · 1985 to 2026
$181.4MStatistical MethodsP01CA087969 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ROSNER, BERNARD A · 2000 to 2019
$77.8MValidity of Diet and Activity Measures in WomenP01CA055075 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI GIOVANNUCCI, EDWARD · 1991 to 2009
$41.8MTissue and Pathology ResourcesP50CA127003 · NCI · DANA-FARBER CANCER INST · PI BASS, ADAM JOEL · 2007 to 2023
$33.2MTranslational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RICHARD M. PEEK · 2002 to 2026
$29.9MJH/CIDR Genotyping for Genome-Wide Association StudiesU01HG004438 · NHGRI · JOHNS HOPKINS UNIVERSITY · PI VALLE, DAVID · 2007 to 2011
$24.2MMolecular pathological epidemiology of colorectal cancerU01CA137088 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI PETERS, ULRIKE · 2009 to 2018
$21.8MUSC Consortium:Colorectal Cancer Family RegistryU01CA074799 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HAILE, ROBERT WILLIAM · 1997 to 2008
$20.4MUniversity of Michigan Training Program in Genomic ScienceT32HG000040 · NHGRI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Sebastian Zoellner · 1995 to 2026
$16.4MSEATTLE FAMILIAL COLORECTAL CANCER REGISTRYU01CA074794 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI NEWCOMB, POLLY A · 1997 to 2007
$14.1MONTARIO REGISTRY FOR STUDIES OF FAMILIAL COLON CANCERU01CA074783 · NCI · CANCER CARE ONTARIO · PI GALLINGER, STEVEN · 1997 to 2008
$12.5MDetection of Colorectal Cancer Susceptibility Loci Using Genome-Wide SequencingU01CA164930 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI PETERS, ULRIKE · 2012 to 2015
$12.4MIntramural NIH HHS Z01 CP010200NCI NIH HHS K05 CA154337NCI NIH HHS K05CA154337NCI NIH HHS P01 CA055075NCI NIH HHS P01CA055075NCI NIH HHS P01 CA087969NCI NIH HHS P01CA087969NCI NIH HHS P30 CA014089NCI NIH HHS P30CA014089NCI NIH HHS P50 CA127003NCI NIH HHS P50CA127003NCI NIH HHS R01 CA042182NCI NIH HHS R01CA042182NCI NIH HHS R01 CA048998NCI NIH HHS R01CA048998NCI NIH HHS R01 CA059045NCI NIH HHS R01CA059045NCI NIH HHS R01 CA064277NCI NIH HHS R01CA064277NCI NIH HHS R01 CA076366NCI NIH HHS R01CA076366NCI NIH HHS R01 CA081488NCI NIH HHS R01 CA082729NCI NIH HHS R01CA082729NCI NIH HHS R01 CA092585NCI NIH HHS R01CA092585NCI NIH HHS R01 CA122364NCI NIH HHS R01CA122364NCI NIH HHS R01 CA124558NCI NIH HHS R01CA124558NCI NIH HHS R01 CA148667NCI NIH HHS R01CA148667NCI NIH HHS R01 CA188214NCI NIH HHS R01CA81488NCI NIH HHS R37 CA070867NCI NIH HHS R37CA070867NCI NIH HHS U01 CA074783NCI NIH HHS U01CA074783NCI NIH HHS U01 CA074794NCI NIH HHS U01CA074794NCI NIH HHS U01 CA074799NCI NIH HHS U01CA074799NCI NIH HHS U01 CA074800NCI NIH HHS U01CA074800NCI NIH HHS U01 CA074806NCI NIH HHS U01CA074806NCI NIH HHS U01 CA097735NCI NIH HHS U01CA097735NCI NIH HHS U01 CA122839NCI NIH HHS U01CA122839NCI NIH HHS U01 CA137088NCI NIH HHS U01CA137088NCI NIH HHS U01 CA164930NCI NIH HHS U19 CA148107NCI NIH HHS U24 CA074783NCI NIH HHS U24 CA074794NCI NIH HHS U24 CA074800NCI NIH HHS U24 CA097735NCI NIH HHS UM1 CA167551NCI NIH HHS UM1 CA167552NCI NIH HHS UM1CA167552NCI NIH HHS UM1 CA173640NCI NIH HHS UM1 CA182910NCI NIH HHS Z01CP 010200NHGRI NIH HHS T32 HG000040NHGRI NIH HHS T32HG000040NHGRI NIH HHS U01 HG004438NHGRI NIH HHS U01HG 004438NHGRI NIH HHS U01 HG004446NHGRI NIH HHS U01HG004446NHLBI NIH HHS HHSN268201100001INHLBI NIH HHS HHSN268201100002INHLBI NIH HHS HHSN268201100003INHLBI NIH HHS HHSN268201100004INHLBI NIH HHS HHSN268201100046CNIA NIH HHS HHSN271201100004CNIDDK NIH HHS P30 DK058404NIEHS NIH HHS T32 ES013678NIEHS NIH HHS T32ES013678WHI NIH HHS HHSN268201100001CWHI NIH HHS HHSN268201100002CWHI NIH HHS HHSN268201100003CWHI NIH HHS HHSN268201100004C
Abstract
Known genetic loci explain only a small proportion of the familial relative risk of colorectal cancer (CRC). We conducted a genome-wide association study of CRC in East Asians with 14,963 cases and 31,945 controls and identified 6 new loci associated with CRC risk (P = 3.42 × 10(-8) to 9.22 × 10(-21)) at 10q22.3, 10q25.2, 11q12.2, 12p13.31, 17p13.3 and 19q13.2. Two of these loci map to genes (TCF7L2 and TGFB1) with established roles in colorectal tumorigenesis. Four other loci are located in or near genes involved in transcriptional regulation (ZMIZ1), genome maintenance (FEN1), fatty acid metabolism (FADS1 and FADS2), cancer cell motility and metastasis (CD9), and cell growth and differentiation (NXN). We also found suggestive evidence for three additional loci associated with CRC risk near genome-wide significance at 8q24.11, 10q21.1 and 10q24.2. Furthermore, we replicated 22 previously reported CRC-associated loci. Our study provides insights into the genetic basis of CRC and suggests the involvement of new biological pathways.
Indexed as
Genetic LociGenome-Wide Association StudyAsian PeopleCase-Control StudiesChinaChromosome MappingColorectal NeoplasmsComputational BiologyDelta-5 Fatty Acid DesaturaseFemaleGene Expression ProfilingGenetic Predisposition to DiseaseGenetic VariationGenotypeHumansJapanDelta-5 Fatty Acid Desaturase
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.