ArticlePloS one2014
Active invasion of oral and aortic tissues by Porphyromonas gingivalis in mice causally links periodontitis and atherosclerosis.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 121 papers, 1 of them a synthesis that pooled it.
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The trial behind it
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Who cites it
121 citing papers in PubMed, 1 synthesis or guideline pooled it, 193 citations in OpenAlex.
- Is Periodontitis Associated with Age-Related Cognitive Impairment? The Systematic Review, Confounders Assessment and Meta-Analysis of Clinical Studies.International journal of molecular sciences · 2022Pooled it
- Periodontal Inflamed Surface Area Mediates the Link between Homocysteine and Blood Pressure.Biomolecules · 2021Trial
- Periodontal biomarkers in cardiovascular disease: mechanisms, diagnostics, and clinical implications.Infection · 2026Review
- Impact of severe periodontitis and diabetes mellitus on recurrent cardiovascular outcomes.Journal of periodontology · 2026Article
- Increased cardiovascular disease risk in patients with periodontal disease: Insights from studies of periodontal treatment.American heart journal plus : cardiology research and practice · 2026Review
- A critical review on the roles of natural products in shaping oral microbiota and preventing chronic diseases.Natural products and bioprospecting · 2026Review
- Bidirectional relationship between the biofilm ofMicrobiology spectrum · 2026Article
- A Novel Role for the Small Molecule Cinnamaldehyde in Protecting AgainstAntioxidants (Basel, Switzerland) · 2026Article
- The Association of Periodontitis and Stroke History: Exploring the Role of Hypertension in a Cross-Sectional NHANES Analysis.International journal of dentistry · 2026Article
- Possible association between the microbiota in subgingival and atherosclerotic plaque in a cohort of patients with carotid stenosis.Journal of oral microbiology · 2026Article
- Bridging oral and systemic health: exploring pathogenesis, biomarkers, and diagnostic innovations in periodontal disease.Infection · 2025Review
- Unraveling the mechanisms of bone diseases: targeting dendritic cells in osteoimmunology for internal homeostasis balance.Bone research · 2025Review
- The Periodontal-Cardiovascular Disease Association: Molecular Mechanisms and Clinical Implications.International journal of molecular sciences · 2025Review
- The Role of TLRs in Obesity and Its Related Metabolic Disorders.International journal of molecular sciences · 2025Review
- Murine Models in Oral Research: A Narrative Review of Experimental Approaches and Cardiovascular Implications.Biology · 2025Review
- Polybacterial Periodontal Infection Alters oxidative and Inflammatory Biomarkers in Primary Human Aortic Endothelial Cell (pHAECs).Journal of pharmacy and pharmacology research · 2025Article
- Research progress on the role of microbiota in the pathogenesis of gallstone disease.Frontiers in microbiology · 2025Review
- Identification of Key Periodontitis Genes and Their Mechanisms of Action Using Comprehensive Multiple Microarray Analysis and Mendelian Randomization Methods.International journal of genomics · 2025Article
- The Bidirectional Relationship Between Cardiovascular Medications and Oral and Gut Microbiome Health: A Comprehensive Review.Microorganisms · 2024Review
- Probing the oral-brain connection: oral microbiome patterns in a large community cohort with anxiety, depression, and trauma symptoms, and periodontal outcomes.Translational psychiatry · 2024Article
61 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
Atherosclerotic vascular disease is a leading cause of myocardial infarction and cerebrovascular accident, and independent associations with periodontal disease (PD) are reported. PD is caused by polymicrobial infections and aggressive immune responses. Genomic DNA of Porphyromonas gingivalis, the best-studied bacterial pathogen associated with severe PD, is detected within atherosclerotic plaque. We examined causal relationships between chronic P. gingivalis oral infection, PD, and atherosclerosis in hyperlipidemic ApoEnull mice. ApoEnull mice (n = 24) were orally infected with P. gingivalis for 12 and 24 weeks. PD was assessed by standard clinical measurements while the aorta was examined for atherosclerotic lesions and inflammatory markers by array. Systemic inflammatory markers serum amyloid A, nitric oxide, and oxidized low-density lipoprotein were analyzed. P. gingivalis infection elicited specific antibodies and alveolar bone loss. Fluorescent in situ hybridization detected viable P. gingivalis within oral epithelium and aorta, and genomic DNA was detected within systemic organs. Aortic plaque area was significantly increased in P. gingivalis-infected mice at 24 weeks (P<0.01). Aortic RNA and protein arrays indicated a strong Th2 response. Chronic oral infection with P. gingivalis results in a specific immune response, significant increases in oral bone resorption, aortic inflammation, viable bacteria in oral epithelium and aorta, and plaque development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.