ArticlePloS one2014
Impact of host age and parity on susceptibility to severe urinary tract infection in a murine model.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 28 citations in OpenAlex.
- The Prevalence of Asymptomatic Bacteriuria Among Jordanian Pregnant Women.International journal of women's health · 2025Article
- Therapeutic effects of orally administration of viable and inactivated probiotic strains against murine urinary tract infection.Journal of food and drug analysis · 2023Review
- Article
- Dipstick urinalysis does not predict post-urodynamic study morbidity.International urogynecology journal · 2023Article
- A mouse model displays host and bacterial strain differences in Aerococcus urinae urinary tract infection.Biology open · 2021Article
- Interstitial cystitis/bladder pain syndrome and recurrent urinary tract infection and the potential role of the urinary microbiome.Post reproductive health · 2020Review
- The Impact of Age and Sex on Mouse Models of Melioidosis.Pathogens (Basel, Switzerland) · 2020Article
- Roles of the vagina and the vaginal microbiota in urinary tract infection: evidence from clinical correlations and experimental models.GMS infectious diseases · 2020Review
- Direct Detection of Tissue-Resident Bacteria and Chronic Inflammation in the Bladder Wall of Postmenopausal Women with Recurrent Urinary Tract Infection.Journal of molecular biology · 2019Review
- Host restriction of Escherichia coli recurrent urinary tract infection occurs in a bacterial strain-specific manner.PLoS pathogens · 2018Article
- Urine Cytokine and Chemokine Levels Predict Urinary Tract Infection Severity Independent of Uropathogen, Urine Bacterial Burden, Host Genetics, and Host Age.Infection and immunity · 2018Article
- Group B Streptococcal Maternal Colonization and Neonatal Disease: Molecular Mechanisms and Preventative Approaches.Frontiers in pediatrics · 2018Review
- Transient microbiota exposures activate dormant Escherichia coli infection in the bladder and drive severe outcomes of recurrent disease.PLoS pathogens · 2017Article
- An Overview of Two-Component Signal Transduction Systems Implicated in Extra-Intestinal PathogenicFrontiers in cellular and infection microbiology · 2017Review
- A mucosal imprint left by prior Escherichia coli bladder infection sensitizes to recurrent disease.Nature microbiology · 2016Article
- The unexplored relationship between urinary tract infections and the autonomic nervous system.Autonomic neuroscience : basic & clinical · 2016Review
- A New Catalog of Microbiological Tools for Women's Infectious Disease Research.Genome announcements · 2016Article
- Strengths and Limitations of Model Systems for the Study of Urinary Tract Infections and Related Pathologies.Microbiology and molecular biology reviews : MMBR · 2016Review
- Gram-Positive Uropathogens, Polymicrobial Urinary Tract Infection, and the Emerging Microbiota of the Urinary Tract.Microbiology spectrum · 2016Review
- Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
The epidemiology and bacteriology of urinary tract infection (UTI) varies across the human lifespan, but the reasons for these differences are poorly understood. Using established monomicrobial and polymicrobial murine UTI models caused by uropathogenic Escherichia coli (UPEC) and/or Group B Streptococcus (GBS), we demonstrate age and parity as inter-related factors contributing to UTI susceptibility. Young nulliparous animals exhibited 10-100-fold higher bacterial titers compared to older animals. In contrast, multiparity was associated with more severe acute cystitis in older animals compared to age-matched nulliparous controls, particularly in the context of polymicrobial infection where UPEC titers were ∼1000-fold higher in the multiparous compared to the nulliparous host. Multiparity was also associated with significantly increased risk of chronic high titer UPEC cystitis and ascending pyelonephritis. Further evidence is provided that the increased UPEC load in multiparous animals required TLR4-signaling. Together, these data strongly suggest that the experience of childbearing fundamentally and permanently changes the urinary tract and its response to pathogens in a manner that increases susceptibility to severe UTI. Moreover, this murine model provides a system for dissecting these and other lifespan-associated risk factors contributing to severe UTI in at-risk groups.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.