ArticleJournal of chromatography. A2014
Enantiomeric separation of biaryl atropisomers using cyclofructan based chiral stationary phases.
Article in Journal of chromatography. A, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Separation of atropisomers by chiral liquid chromatography and thermodynamic analysis of separation mechanism.Journal of pharmaceutical analysis · 2017Article
- Screening primary racemic amines for enantioseparation by derivatized polysaccharide and cyclofructan columns.Journal of pharmaceutical analysis · 2016Article
- Applied circular dichroism: a facile spectroscopic tool for configurational assignment and determination of enantiopurity.Journal of analytical methods in chemistry · 2015Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Normal phase chiral HPLC methods are presented for the enantiomeric separation of 30 biaryl atropisomers including 18 new compounds recently produced via a novel synthetic approach. Three new cyclofructan based chiral stationary phases were evaluated. Separations were achieved for all but six analytes and the LARIHC™ CF6-P alone provided 15 baseline separations. Effects of polar modifiers and temperature effects also were studied. Apparent thermodynamic parameters were determined by van't Hoff plots. Preparative scale methods were developed and employed resulting in the first ever isolation of these novel atropisomers in their pure enantiomeric form. Insights into the mechanism of retention and chiral discrimination are presented.
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Registered trials
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