ArticleDevelopmental cell2014
Developmentally regulated elimination of damaged nuclei involves a Chk2-dependent mechanism of mRNA nuclear retention.
Article in Developmental cell, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 39 citations in OpenAlex.
- Elevated temperature fatally disrupts nuclear divisions in the early Drosophila embryo.Nature communications · 2026Article
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- Integration of a multi-omics stem cell differentiation dataset using a dynamical model.PLoS genetics · 2023Article
- Cross Talk proposal: Myonuclei are lost with ageing and atrophy.The Journal of physiology · 2022Article
- Distinct spermiogenic phenotypes underlie sperm elimination in the Segregation Distorter meiotic drive system.PLoS genetics · 2021Article
- A region of SLBP outside the mRNA-processing domain is essential for deposition of histone mRNA into theJournal of cell science · 2021Article
- Alternative linker histone permits fast paced nuclear divisions in early Drosophila embryo.Nucleic acids research · 2020Article
- Organelle size scaling over embryonic development.Wiley interdisciplinary reviews. Developmental biology · 2020Review
- Histone concentration regulates the cell cycle and transcription in early development.Development (Cambridge, England) · 2019Article
- A Drosophila cell-free system that senses DNA breaks and triggers phosphorylation signalling.Nucleic acids research · 2019Article
- Metabolic Regulation of Developmental Cell Cycles and Zygotic Transcription.Current biology : CB · 2019Article
- TheThe Journal of cell biology · 2019Article
- Coordination of Embryogenesis by the Centrosome in Drosophila melanogaster.Results and problems in cell differentiation · 2019Review
- Flying the RNA Nest: Drosophila Reveals Novel Insights into the Transcriptome Dynamics of Early Development.Journal of developmental biology · 2018Review
- CeFra-seq reveals broad asymmetric mRNA and noncoding RNA distribution profiles inRNA (New York, N.Y.) · 2018Article
- Cell Cycle Control by Nuclear Sequestration of CDC20 and CDH1 mRNA in Plant Stem Cells.Molecular cell · 2017Article
- Essential Function of the Serine Hydroxymethyl Transferase (SHMT) Gene During Rapid Syncytial Cell Cycles inG3 (Bethesda, Md.) · 2017Article
- Loss of function of the Drosophila Ninein-related centrosomal protein Bsg25D causes mitotic defects and impairs embryonic development.Biology open · 2016Article
- Early development of Drosophila embryos requires Smc5/6 function during oogenesis.Biology open · 2016Article
- The Seckel syndrome and centrosomal protein Ninein localizes asymmetrically to stem cell centrosomes but is not required for normal development, behavior, or DNA damage response in Drosophila.Molecular biology of the cell · 2016Article
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9 authors at 2 institutions in 1 country.
Funding
Abstract
The faithful execution of embryogenesis relies on the ability of organisms to respond to genotoxic stress and to eliminate defective cells that could otherwise compromise viability. In syncytial-stage Drosophila embryos, nuclei with excessive DNA damage undergo programmed elimination through an as-yet poorly understood process of nuclear fallout at the midblastula transition. We show that this involves a Chk2-dependent mechanism of mRNA nuclear retention that is induced by DNA damage and prevents the translation of specific zygotic mRNAs encoding key mitotic, cytoskeletal, and nuclear proteins required to maintain nuclear viability. For histone messages, we show that nuclear retention involves Chk2-mediated inactivation of the Drosophila stem loop binding protein (SLBP), the levels of which are specifically depleted in damaged nuclei following Chk2 phosphorylation, an event that contributes to nuclear fallout. These results reveal a layer of regulation within the DNA damage surveillance systems that safeguard genome integrity in eukaryotes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.