ArticlePloS one2014
The significance of screening for microvascular diseases in Chinese community-based subjects with various metabolic abnormalities.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Relation of metabolic syndrome and its components with risk of diabetic retinopathy: A meta-analysis of observational studies.Medicine · 2018Pooled it
- The Association of Metabolic Syndrome with Diabetic Retinopathy: The Korean National Health and Nutrition Examination Survey 2008-2012.PloS one · 2016Trial
- Article
- Association Between Different Metabolic Markers and Metabolic Syndrome in an Outpatient Hyperuricemia Population: A Cross-Sectional Study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2023Article
- Serum Uric Acid to Creatinine Ratio and Risk of Metabolic Syndrome in Patients with Overweight/Obesity.Diabetes, metabolic syndrome and obesity : targets and therapy · 2023Article
- Identifying Metabolic Syndrome Easily and Cost Effectively Using Non-Invasive Methods with Machine Learning Models.Diabetes, metabolic syndrome and obesity : targets and therapy · 2023Article
- Association of the serum uric acid to creatinine ratio with metabolic syndrome in the middle age and older population in China.Frontiers in endocrinology · 2022Article
- Higher prevalence of diabetic retinopathy among female Chinese diabetic patients with metabolic syndrome.Japanese journal of ophthalmology · 2022Article
- Prevalence and risk factors of diabetic retinopathy in diabetic patients: A community based cross-sectional study.Medicine · 2020Article
- Article
- Association between metabolic syndrome and knee osteoarthritis: a cross-sectional study.BMC musculoskeletal disorders · 2017Observational
- A panel of free fatty acid ratios to predict the development of metabolic abnormalities in healthy obese individuals.Scientific reports · 2016Article
- Prevalence and risk factors of retinopathy in patients with or without metabolic syndrome: a population-based study in Shenyang.BMJ open · 2015Article
- Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo assess the association of albuminuria and retinopathy with metabolic syndrome (MetS) and the related metabolic components defined by various criteria in Chinese community-based subjects.
methodsA total of 3240 Chinese subjects were recruited from urban communities and classified into subgroups with isolated or concomitant state of the two microvascular diseases. MetS was defined according to the standard of International Diabetes Federation, the National Cholesterol Education Program's Adult Treatment Panel III and Chinese Diabetes Society (CDS), separately. Albuminuria was defined as an elevated morning urine albumin-to-creatinine ratio. Retinopathy were identified with nonmydriatic retinal photographs according to the Diabetic Retinopathy Disease Severity Scale. Logistic regression was performed to analyze the contributive risk factors.
resultsThe subgroup of isolated retinopathy was the oldest (P<0.05), with higher blood pressure (P<0.001) and larger waist circumference (P<0.05). After adjusting for age, sex and other metabolic components, individuals with blood pressure over 130/85 mmHg were prone to have isolated albuminuria (OR: 1.51, P = 0.0001); while individuals with fasting plasma glucose over 5.6 mmol/L were in high risk of retinopathy concomitant with albuminria (OR: 3.04, P = 0.006). Larger waist circumference was a potential risk factors for isolated albuminuria and isolated retinopathy, though not significant after further adjustment of other metabolic components. The risk for albuminuria and retinopathy increased with the aggregation of three or more metabolic components. However, the MetS per se did not have synergic effect and only the MetS defined by CDS remained as a risk factor.
conclusionsAlbuminuria and retinopathy were highly associated with accumulated metabolic abnormalities including sub-clinical elevated blood pressure and elevated fasting plasma glucose.
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