ReviewThe Journal of physiology2014
High affinity and low affinity heteromeric nicotinic acetylcholine receptors at central synapses.
Review in The Journal of physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 19 citations in OpenAlex.
- Targeting Alpha7 Nicotinic Acetylcholine Receptors in Lung Cancer: Insights, Challenges, and Therapeutic Strategies.ACS pharmacology & translational science · 2024Review
- Cholinergic Modulation of Locomotor Circuits in Vertebrates.International journal of molecular sciences · 2022Review
- Stoichiometry-selective modulation of α4β2 nicotinic ACh receptors by divalent cations.British journal of pharmacology · 2022Article
- Effect of Intrahippocampal Administration of α7 Subtype Nicotinic Receptor Agonist PNU-282987 and Its Solvent Dimethyl Sulfoxide on the Efficiency of Hypoxic Preconditioning in Rats.Molecules (Basel, Switzerland) · 2021Article
- Deorphanization of novel biogenic amine-gated ion channels identifies a new serotonin receptor for learning.Current biology : CB · 2021Article
- Developmental plasticity of GABAergic neurotransmission to brainstem motoneurons.The Journal of physiology · 2018Article
- Stoichiometry of the Heteromeric Nicotinic Receptors of the Renshaw Cell.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Single nucleotide polymorphisms and genotypes of transient receptor potential ion channel and acetylcholine receptor genes from isolated B lymphocytes in myalgic encephalomyelitis/chronic fatigue syndrome patients.The Journal of international medical research · 2016Article
- The nicotinic acetylcholine receptor alpha 4 subunit contains a functionally relevant SNP Haplotype.BMC genetics · 2015Article
- Synaptic mechanisms underlying cholinergic control of thalamic reticular nucleus neurons.The Journal of physiology · 2014Review
- Synaptic properties and functional consequences of cholinergic signalling in the mammalian CNS.The Journal of physiology · 2014Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Most neuronal heteromeric nicotinic receptors seem able to adopt two different stochiometries depending on the ratio of α and β subunits. In recombinant receptors these two stoichiometries have been associated with different affinities to ACh, but it is not known which stoichiometry is present at nicotinic synapses in the nervous system. One possible clue to this identification is the speed of decay of the synaptic currents. In many ionotropic receptors this speed has been linked to the dissociation rate of the transmitter, which is itself related to its affinity. On this basis we propose that, at the synapse between motoneuron and Renshaw cells, the heteromeric nicotinic receptors are mostly low affinity receptors and suggest that, in contrast, the very slow decay of some synaptic currents recorded in other parts of the brain signs the presence of high affinity receptors rather than volume transmission.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.