ArticleJournal of visualized experiments : JoVE2014
Isolation and culture of dental epithelial stem cells from the adult mouse incisor.
Article in Journal of visualized experiments : JoVE, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 23 citations in OpenAlex.
- Med1 deletion reprograms dental epithelium into a hair-forming epidermal architecture associated with Trp63 induction.Biochemistry and biophysics reports · 2026Article
- Benzo[a]pyrene exposure affect the formation of dental hard tissue via the regulation of glycerophospholipid metabolism.BMC oral health · 2026Article
- Adult dental epithelial stem cell-derived organoids deposit hydroxylapatite biomineral.International journal of oral science · 2023Article
- CGRP and Shh Mediate the Dental Pulp Cell Response to Neuron Stimulation.Journal of dental research · 2022Article
- Epigenetic controls of Sonic hedgehog guarantee fidelity of epithelial adult stem cells trajectory in regeneration.Science advances · 2022Article
- SRSF1 governs progenitor-specific alternative splicing to maintain adult epithelial tissue homeostasis and renewal.Developmental cell · 2022Article
- Epiprofin Transcriptional Activation Promotes Ameloblast Induction From Mouse Induced Pluripotent Stem CellsFrontiers in bioengineering and biotechnology · 2022Article
- Stage-Specific Role ofInternational journal of molecular sciences · 2021Article
- Propagation of Dental and Respiratory Cells and Organs in Microgravity.Journal of visualized experiments : JoVE · 2021Article
- Hard Dental Tissues Regeneration-Approaches and Challenges.Materials (Basel, Switzerland) · 2021Review
- Special AT-rich sequence-binding protein 2 (Satb2) synergizes with Bmp9 and is essential for osteo/odontogenic differentiation of mouse incisor mesenchymal stem cells.Cell proliferation · 2021Article
- FAM20B-catalyzed glycosaminoglycans control murine tooth number by restricting FGFR2b signaling.BMC biology · 2020Article
- Single-Cell RNA-Sequencing From Mouse Incisor Reveals Dental Epithelial Cell-Type Specific Genes.Frontiers in cell and developmental biology · 2020Article
- Stem cells and tooth regeneration: prospects for personalized dentistry.The EPMA journal · 2019Review
- Enamel biomimetics-fiction or future of dentistry.International journal of oral science · 2019Review
- Micro-dissection of Enamel Organ from Mandibular Incisor of Rats Exposed to Environmental Toxicants.Journal of visualized experiments : JoVE · 2018Article
- Resolving stem and progenitor cells in the adult mouse incisor through gene co-expression analysis.eLife · 2017Article
- Generation of Spheres from Dental Epithelial Stem Cells.Frontiers in physiology · 2017Article
- BMP-SHH signaling network controls epithelial stem cell fate via regulation of its niche in the developing tooth.Developmental cell · 2015Article
- In vivo administration of dental epithelial stem cells at the apical end of the mouse incisor.Frontiers in physiology · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 4 countries.
Funding
Abstract
Understanding the cellular and molecular mechanisms that underlie tooth regeneration and renewal has become a topic of great interest(1-4), and the mouse incisor provides a model for these processes. This remarkable organ grows continuously throughout the animal's life and generates all the necessary cell types from active pools of adult stem cells housed in the labial (toward the lip) and lingual (toward the tongue) cervical loop (CL) regions. Only the dental stem cells from the labial CL give rise to ameloblasts that generate enamel, the outer covering of teeth, on the labial surface. This asymmetric enamel formation allows abrasion at the incisor tip, and progenitors and stem cells in the proximal incisor ensure that the dental tissues are constantly replenished. The ability to isolate and grow these progenitor or stem cells in vitro allows their expansion and opens doors to numerous experiments not achievable in vivo, such as high throughput testing of potential stem cell regulatory factors. Here, we describe and demonstrate a reliable and consistent method to culture cells from the labial CL of the mouse incisor.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.