ArticleJournal of cellular and molecular medicine2014
Modulation of adipocyte differentiation by omega-3 polyunsaturated fatty acids involves the ubiquitin-proteasome system.
Article in Journal of cellular and molecular medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 44 citations in OpenAlex.
- Article
- Omega-3 polyunsaturated fatty acids and its metabolite 12-HEPE rescue busulfan disrupted spermatogenesis via target to GPR120.Cell proliferation · 2024Article
- Valorization of Side Stream Products from Sea Cage Fattened Bluefin Tuna (Marine drugs · 2022Article
- Association between maternal erythrocyte polyunsaturated fatty acid levels during pregnancy and offspring weight status: A birth cohort study.Frontiers in nutrition · 2022Article
- Perspectives on scaling production of adipose tissue for food applications.Biomaterials · 2022Article
- Evaluating the effect of arachidonic acid and eicosapentaenoic acid on induction of adipogenesis in human adipose-derived stem cells.Iranian journal of basic medical sciences · 2020Article
- Short-Term Responses to Fatty Acids on Lipid Metabolism and Adipogenesis in Rainbow Trout (International journal of molecular sciences · 2020Article
- Concurrent EPA and DHA Supplementation Impairs Brown Adipogenesis of C2C12 Cells.Frontiers in genetics · 2020Article
- Determination of Fat Accumulation Reduction by Edible Fatty Acids and Natural WaxesFood science of animal resources · 2019Article
- Omega-3 polyunsaturated fatty acids attenuate inflammatory activation and alter differentiation in human adipocytes.The Journal of nutritional biochemistry · 2019Article
- LncRNA IMFNCR Promotes Intramuscular Adipocyte Differentiation by Sponging miR-128-3p and miR-27b-3p.Frontiers in genetics · 2019Article
- Long-Chain Omega-3 Polyunsaturated Fatty Acids Modulate Mammary Gland Composition and Inflammation.Journal of mammary gland biology and neoplasia · 2018Article
- Profiling of differentially expressed genes in adipose tissues of multiple symmetric lipomatosis.Molecular medicine reports · 2017Article
- Suppression of adipocyte differentiation and lipid accumulation by stearidonic acid (SDA) in 3T3-L1 cells.Lipids in health and disease · 2017Article
- A Nutrigenomic Approach to Non-Alcoholic Fatty Liver Disease.International journal of molecular sciences · 2017Review
- Critical role of the peroxisomal protein PEX16 in white adipocyte development and lipid homeostasis.Biochimica et biophysica acta. Molecular and cell biology of lipids · 2017Article
- Docosahexaenoic acid-mediated protein aggregates may reduce proteasome activity and delay myotube degradation during muscle atrophy in vitro.Experimental & molecular medicine · 2017Article
- Polymorphisms in stearoyl coa desaturase and sterol regulatory element binding protein interact with N-3 polyunsaturated fatty acid intake to modify associations with anthropometric variables and metabolic phenotypes in Yup'ik people.Molecular nutrition & food research · 2016Article
- Differentiation of preadipocytes and mature adipocytes requires PSMB8.Scientific reports · 2016Article
- N-3 Polyunsaturated Fatty Acids of Marine Origin and Multifocality in Human Breast Cancer.PloS one · 2016Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have evaluated the effects of three different omega-3 polyunsaturated fatty acids (ω-3 PUFAs) – docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA) and docosapentaenoic acid (DPA) on fat accumulation and expression of adipogenic and inflammatory markers using both 3T3-L1 pre-adipocytes and differentiated 3T3-L1 adipocytes. Our results indicate that ω-3 PUFAs induce the degradation of fatty acid synthase through the ubiquitin-proteasome system, which is likely to have beneficial metabolic effect on adipose cells. Omega-3 PUFAs also increase overall levels of polyubiquitinated proteins, at least in part through decreasing the expression of proteasome subunits. Moreover, adipocytes are resistant to proteasome inhibition, which induces adipophilin while decreasing perilipin expression. On the other hand, ω-3 PUFAs decrease expression of SREBP1 while inducing expression of adipophilin and GLUT4. Moreover, all three ω-3 PUFAs appear to induce tumour necrosis factor-α without affecting NFκB levels. All three ω-3 PUFAs appear to have overall similar effects. Further research is needed to elucidate their mechanism of action.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.