Evidence map›Paper›PMID 24834416›Full record

ArticleCardiovascular diagnosis and therapy2014

Magnetic resonance imaging as a tool to assess reliability in simulating hemodynamics in cerebral aneurysms with a dedicated computational fluid dynamics prototype: preliminary results.

Christof Karmonik, Y Jonathan Zhang, Orlando Diaz, Richard Klucznik, Sasan Partovi, Robert G Grossman, Gavin W Britz

Open access · greenAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Cardiovascular diagnosis and therapy, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Reconstructing patient-specific cerebral aneurysm vasculature for in vitro investigations and treatment efficacy assessments.Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia · 2019
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Christof Karmonik1 Department of Neurosurgery, 2 Department of Radiology, Houston Methodist Hospital, Houston, TX 77030, USA ; 3 Department of Internal Medicine, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, Ohio, USA.
Y Jonathan Zhang1 Department of Neurosurgery, 2 Department of Radiology, Houston Methodist Hospital, Houston, TX 77030, USA ; 3 Department of Internal Medicine, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, Ohio, USA.
Orlando Diaz1 Department of Neurosurgery, 2 Department of Radiology, Houston Methodist Hospital, Houston, TX 77030, USA ; 3 Department of Internal Medicine, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, Ohio, USA.
Richard Klucznik1 Department of Neurosurgery, 2 Department of Radiology, Houston Methodist Hospital, Houston, TX 77030, USA ; 3 Department of Internal Medicine, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, Ohio, USA.
Sasan Partovi1 Department of Neurosurgery, 2 Department of Radiology, Houston Methodist Hospital, Houston, TX 77030, USA ; 3 Department of Internal Medicine, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, Ohio, USA.
Robert G Grossman1 Department of Neurosurgery, 2 Department of Radiology, Houston Methodist Hospital, Houston, TX 77030, USA ; 3 Department of Internal Medicine, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, Ohio, USA.
Gavin W Britz1 Department of Neurosurgery, 2 Department of Radiology, Houston Methodist Hospital, Houston, TX 77030, USA ; 3 Department of Internal Medicine, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, Ohio, USA.
University Hospitals of Cleveland · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeAs an example of enhancing information in clinical image data by computational methods, simulating hemodynamics in cerebral aneurysms by means of computational fluid dynamics (CFD) is currently a topic of active research. Challenges consist in translating this engineering technology into clinical research, validating the simulations and addressing a potential clinical value of the results. In this preliminary study, we demonstrate the use of phase contrast magnetic resonance imaging (pcMRI) for assessing the reliability of CFD results. MATERIALS AND

methodsFor six cerebral aneurysms where intra-aneurysmal velocity information was available by 2D pcMRI, steady CFD simulations with constant inflow were performed using a dedicated CFD prototype system. Major features of the velocity patterns derived from pcMRI were compared to those obtained with the CFD.

resultsGood qualitative agreement between measured (2D pcMRI) and simulated (CFD) features of the intra-aneurysmal velocity patterns were obtained. These findings are discussed in the broader framework of the expectations towards CFD simulations in a clinical research setting.

conclusionsComputational simulations reproduce major features of measured velocity patterns in cerebral aneurysms. Looking forward, these simulations need to be refined towards specific applications in clinical research.

Indexed as

aneurysm ruptureCerebral aneurysmscomputational fluid dynamics (CFD)

Identifiers

PMID24834416
PMCPMC3996232
OpenAlexW66395050

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.