ReviewWorld journal of critical care medicine2014
Controversies in fluid therapy: Type, dose and toxicity.
Review in World journal of critical care medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05239286 (Comparison Between Conventional Fluid Management and Plethysmographic Variability Index Based Goal Directed Fluid Management in Patients Undergoing Spine Surgeries in Prone Position; A Randomized Control Trial.), which is not on this map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Comparison Between Conventional Fluid Management and Plethysmographic Variability Index Based Goal Directed Fluid Management in Patients Undergoing Spine Surgeries in Prone Position; A Randomized Control Trial.
Who cites it
18 citing papers in PubMed, 62 citations in OpenAlex.
- Conventional fluid management versus plethysmographic variability index-based goal directed fluid management in patients undergoing spine surgery in the prone position - a randomised control trial.Anaesthesiology intensive therapy · 2023Trial
- Comparison of conventional fluid management with PVI-based goal-directed fluid management in elective colorectal surgery.Journal of clinical monitoring and computing · 2019Trial
- Clinical Parameters Associated with Achieving Negative Fluid Balance in Critically Ill Patients: A Retrospective Cohort Study.Journal of clinical medicine · 2026Article
- The Pleth Variability Index as a Guide to Fluid Therapy in Dogs Undergoing General Anesthesia: A Preliminary Study.Veterinary sciences · 2024Article
- Pleth Variability Index-Based Goal-Directed Fluid Management in Patients Undergoing Elective Gynecologic Surgery.Sisli Etfal Hastanesi tip bulteni · 2022Article
- Association between Latent Trajectories of Fluid Balance and Clinical Outcomes in Critically Ill Patients with Acute Kidney Injury: A Prospective Multicenter Observational Study.Kidney diseases (Basel, Switzerland) · 2022Article
- Evaluation of the Distribution and Elimination of Balanced Isotonic Crystalloid, 5% Hypertonic Saline, and 6% Tetrastarch 130/0.4 Using Volume Kinetic Modeling and Analysis in Healthy Conscious Cats.Frontiers in veterinary science · 2020Article
- Understanding Volume Kinetics: The Role of Pharmacokinetic Modeling and Analysis in Fluid Therapy.Frontiers in veterinary science · 2020Review
- Intravenous sodium and chloride: not too much, not too quick, and only to healthy kidneys!Journal of thoracic disease · 2019Article
- Principles of fluid management and stewardship in septic shock: it is time to consider the four D's and the four phases of fluid therapy.Annals of intensive care · 2018Review
- Cumulative positive fluid balance is a risk factor for acute kidney injury and requirement for renal replacement therapy after liver transplantation.World journal of transplantation · 2018Article
- Early Liberal Fluid Therapy for Sepsis Patients Is Not Harmful: Hydrophobia Is Unwarranted but Drink Responsibly.Critical care medicine · 2016Review
- The Use of Fluids in Sepsis.Cureus · 2016Review
- Fluid resuscitation practice patterns in intensive care units of the USA: a cross-sectional survey of critical care physicians.Perioperative medicine (London, England) · 2016Article
- Frequency of fluid overload and usefulness of bioimpedance in patients requiring intensive care for sepsis syndromes.Proceedings (Baylor University. Medical Center) · 2016Article
- Fluid and electrolyte overload in critically ill patients: An overview.World journal of critical care medicine · 2015Review
- A comparative study of Sterofundin and Ringer lactate based infusion protocol in scoliosis correction surgery.Anesthesia, essays and researchesArticle
- Intraoperative cardiac complications in liver transplantation: A comprehensive review of management strategies.Saudi journal of anaesthesiaReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fluid therapy is perhaps the most common intervention received by acutely ill hospitalized patients; however, a number of critical questions on the efficacy and safety of the type and dose remain. In this review, recent insights derived from randomized trials in terms of fluid type, dose and toxicity are discussed. We contend that the prescription of fluid therapy is context-specific and that any fluid can be harmful if administered inappropriately. When contrasting ''crystalloid vs colloid'', differences in efficacy are modest but differences in safety are significant. Differences in chloride load and strong ion difference across solutions appear to be clinically important. Phases of fluid therapy in acutely ill patients are recognized, including acute resuscitation, maintaining homeostasis, and recovery phases. Quantitative toxicity (fluid overload) is associated with adverse outcomes and can be mitigated when fluid therapy based on functional hemodynamic parameters that predict volume responsiveness and minimization of non-essential fluid. Qualitative toxicity (fluid type), in particular for iatrogenic acute kidney injury and metabolic acidosis, remain a concern for synthetic colloids and isotonic saline, respectively. Physiologically balanced crystalloids may be the ''default'' fluid for acutely ill patients and the role for colloids, in particular hydroxyethyl starch, is increasingly unclear. We contend the prescription of fluid therapy is analogous to the prescription of any drug used in critically ill patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.