Evidence map›Paper›PMID 24834378›Full record

ArticleCurrent behavioral neuroscience reports2014

Vagus Nerve Stimulation.

Robert H Howland

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current behavioral neuroscience reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04071743 (A Randomized, Single-Center, Double-Blind, Parallel, Sham-Controlled Study of Gammacore Sapphire), which is not on this map. Cited by 186 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
186citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04071743 nawithdrawnnot on this mapstarted 2020, after this paper: background citation

A Randomized, Single-Center, Double-Blind, Parallel, Sham-Controlled Study of Gammacore Sapphire (Non-Invasive Vagus Nerve Stimulator) for the Acute and Preventive Treatment of Post-Traumatic Headache (GAP-PTH)

TypeinterventionalSponsorUniversity of Texas Southwestern Medical CenterRan2020 to 2021Enrolled0ConditionsPost-Traumatic HeadacheArmsgammaCore Sapphire, sham gammaCore Sapphire
3 · Its place in the literature

Who cites it

186 citing papers in PubMed, 7 syntheses or guidelines pooled it.

  1. Pooled it
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  6. Atonic seizures in children: a meta-analysis comparing corpus callosotomy to vagus nerve stimulation.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2021
    Pooled it
  7. Pooled it
  8. Trial
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  11. Review
  12. Article
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  15. Metabolic Brain Disorders: Prodromes, Symptoms, and Syndromes.International journal of molecular sciences · 2026
    Review
  16. Review
  17. Article
  18. Review
  19. Article
  20. Gut-brain axis in health and brain disease.Chinese medical journal · 2026
    Review

126 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Robert H HowlandDepartment of Psychiatry; Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center; Pittsburgh, PA.

Funding

2/3-Improving Depression Outcome by Adding CBT for Insomnia to AntidepressantsR01MH078961 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BUYSSE, DANIEL J. · 2008 to 2012
$1.3M
Pharmacotherapy for Minor DepressionR01MH061394 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HOWLAND, ROBERT H · 2001 to 2004
$1.3M
NIMH NIH HHS R01 MH061394NIMH NIH HHS R01 MH078961
6 · The paper itself

Abstract

The vagus nerve is a major component of the autonomic nervous system, has an important role in the regulation of metabolic homeostasis, and plays a key role in the neuroendocrine-immune axis to maintain homeostasis through its afferent and efferent pathways. Vagus nerve stimulation (VNS) refers to any technique that stimulates the vagus nerve, including manual or electrical stimulation. Left cervical VNS is an approved therapy for refractory epilepsy and for treatment resistant depression. Right cervical VNS is effective for treating heart failure in preclinical studies and a phase II clinical trial. The effectiveness of various forms of non-invasive transcutaneous VNS for epilepsy, depression, primary headaches, and other conditions has not been investigated beyond small pilot studies. The relationship between depression, inflammation, metabolic syndrome, and heart disease might be mediated by the vagus nerve. VNS deserves further study for its potentially favorable effects on cardiovascular, cerebrovascular, metabolic, and other physiological biomarkers associated with depression morbidity and mortality.

Indexed as

cytokinesdepressionepilepsyheart failureimmune systeminflammationmetabolic syndrometranscutaneous vagus nerve stimulationtreatment resistant depressionVagus nervevagus nerve stimulation

Identifiers

PMID24834378
PMCPMC4017164

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.