ReviewScientifica2014
Update on abdominal aortic aneurysm research: from clinical to genetic studies.
Review in Scientifica, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Genetic and clinical determinants of abdominal aortic diameter: genome-wide association studies, exome array data and Mendelian randomization study.Human molecular genetics · 2022Pooled it
- Deficiency of p27Journal of vascular research · 2026Article
- Status of diagnosis and therapy of abdominal aortic aneurysms.Frontiers in cardiovascular medicine · 2023Review
- Two novel presentations of KCNMA1-related pathology--Expanding the clinical phenotype of a rare channelopathy.Molecular genetics & genomic medicine · 2021Article
- MMPs and ADAMs/ADAMTS inhibition therapy of abdominal aortic aneurysm.Life sciences · 2020Review
- Insight into the expression of toll-like receptors 2 and 4 in patients with abdominal aortic aneurysm.Molecular biology reports · 2020Article
- Association of Life's Simple 7 with reduced clinically manifest abdominal aortic aneurysm: The ARIC study.Vascular medicine (London, England) · 2019Article
- Thrombus risk versus bleeding risk: a clinical conundrum.BMJ case reports · 2019Article
- Defective autophagy in vascular smooth muscle cells enhances cell death and atherosclerosis.Autophagy · 2018Article
- Chinese Herbal Medicine as a Potential Treatment of Abdominal Aortic Aneurysm.Frontiers in cardiovascular medicine · 2018Article
- Role of the LDL Receptor-Related Protein 1 in Regulating Protease Activity and Signaling Pathways in the Vasculature.Current drug targets · 2018Review
- Induction of autoimmune abdominal aortic aneurysm in pigs - A novel large animal model.Annals of medicine and surgery (2012) · 2017Article
- Aetiology and management of hereditary aortopathy.Nature reviews. Cardiology · 2017Review
- Increased risk of deep vein thrombosis and pulmonary thromboembolism in patients with aortic aneurysms: A nationwide cohort study.PloS one · 2017Article
- Proteomic analysis in cardiovascular research.Surgery today · 2016Review
- Background differences in baseline and stimulated MMP levels influence abdominal aortic aneurysm susceptibility.Atherosclerosis · 2015Article
- A crosstalk triggered by hypoxia and maintained by MCP-1/miR-98/IL-6/p38 regulatory loop between human aortic smooth muscle cells and macrophages leads to aortic smooth muscle cells apoptosis via Stat1 activation.International journal of clinical and experimental pathology · 2015Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
An abdominal aortic aneurysm (AAA) is a dilatation of the abdominal aorta with a diameter of at least 3.0 cm. AAAs are often asymptomatic and are discovered as incidental findings in imaging studies or when the AAA ruptures leading to a medical emergency. AAAs are more common in males than females, in individuals of European ancestry, and in those over 65 years of age. Smoking is the most important environmental risk factor. In addition, a positive family history of AAA increases the person's risk for AAA. Interestingly, diabetes has been shown to be a protective factor for AAA in many large studies. Hallmarks of AAA pathogenesis include inflammation, vascular smooth muscle cell apoptosis, extracellular matrix degradation, and oxidative stress. Autoimmunity may also play a role in AAA development and progression. In this Outlook paper, we summarize our recent studies on AAA including clinical studies related to surgical repair of AAA and genetic risk factor and large-scale gene expression studies. We conclude with a discussion on our research projects using large data sets available through electronic medical records and biobanks.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.