Evidence map›Paper›PMID 24834285›Full record

ArticleGastroenterology and hepatology from bed to bench2013

Different frequency of epidermal growth factor rs76189946 polymorphism genotype in an Iranian colorectal cancer.

Vahid Chaleshi, Sanaz Savabkar, Hesamodin Dolatmoradi, Mahdi Montazer Haghighi, Elmira Khalili Maryan, Sara Pasha, Narges Ebrahimi Vandfaez, Ehsan Nazemalhosseini Mojarad, Hamid Asadzadeh Aghdaei, Mohammad Reza Zali

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Article in Gastroenterology and hepatology from bed to bench, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Vahid ChaleshiBasic and Molecular Epidemiology of Gastroenterology Disorder Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Sanaz SavabkarBasic and Molecular Epidemiology of Gastroenterology Disorder Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Hesamodin DolatmoradiBasic and Molecular Epidemiology of Gastroenterology Disorder Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Mahdi Montazer HaghighiDepartment of Biology, Science Faculty, Islamic Azad University, East Tehran Branch, Tehran, Iran.
Elmira Khalili MaryanBasic and Molecular Epidemiology of Gastroenterology Disorder Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Sara PashaGastroenterology and Liver Diseases Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Narges Ebrahimi VandfaezBasic and Molecular Epidemiology of Gastroenterology Disorder Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Ehsan Nazemalhosseini MojaradGastroenterology and Liver Diseases Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Hamid Asadzadeh AghdaeiBasic and Molecular Epidemiology of Gastroenterology Disorder Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Mohammad Reza ZaliGastroenterology and Liver Diseases Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Shahid Beheshti University of Medical Sciences · IRIslamic Azad University South Tehran Branch · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimThis study aimed to determinant association between rs76189946 polymorphism of EGF gene and risk of colorectal cancer in an Iranian population.

backgroundColorectal cancer (CRC) is the third most prevalent cancer in both genders worldwide. The determination of genetic variation becomes a new way to etiology of colorectal cancer. Epidermal growth factor (EGF) is a mitogen that plays an important role in cell growth and tumourigenesis, this protein acts by binding its receptor, EGFR. PATIENTS AND

methodsDNA samples taken from totally 125 CRC patients and healthy controls were amplified by polymerase chain reaction (PCR) for the rs76189946 polymorphism. Genotypes were analyzed using restriction fragment length polymorphism (RFLP). Finally to confirm the RFLP procedure, 20 of the PCR products were sequenced using the ABI PRISM 3130xl Genetic Analyzer and chain termination method (Applied Biosystems, Carlsbad, CA).

resultsGenotype distribution and allele frequency was similar in CRC patients and controls individuals. We expect observe C and G allele in both groups but only was found C allele.

conclusionIn this study for first time we identified genetic distribution of exonic rs76189946 polymorphism in EGF gene both CRC patients and healthy controls. These results suggest there wasn't association between EGF polymorphism rs76189946 and risk of colorectal cancer in an Iranian population.

Indexed as

Colorectal cancerEpidermal growth factor (EGF)rs76189946Single nucleotide polymorphism (SNP)

Identifiers

PMID24834285
PMCPMC4017547
OpenAlexW243851611

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