ArticleGastroenterology and hepatology from bed to bench2013
Evaluation of the benefit of addition of clidinium C to a Helicobacter pylori eradication regimen.
Article in Gastroenterology and hepatology from bed to bench, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
6 authors.
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Abstract
aimThis study aimed to evaluate the success of H.pylori eradication therapy in patients with dyspepsia by therapeutics regimes with and without clidinium C.
backgroundHelicobacter pylori infections are reported in all parts of the world. Appropriate antibiotic therapy can treat infection. The ideal treatment regimen has not been specified. PATIENTS AND
methodsIn a randomized, double blind clinical trials study, 250 patients with dyspepsia were enrolled. All patients were treated by Omeprazole, Metronidazole, Amoxicillin and Bismuth (OMAB) for two weeks. One tablet clidinium C before each meal was added to this regimen in the intervention group (A). Urea Breath Test (UBT) was carried out after 8-12 weeks after treatment for evaluation of H.pylori eradication.
results132 patients in the intervention group (A) and 118 patients in the control group (B) were enrolled to the study. The rate of eradication in group A was significantly higher than group B (62.1% vs. 50%, p=0.04).
conclusionThe results supported the effect of clidinium C for increasing of helicobacter pylori eradication, but further studies need to be performed.
Indexed as
Identifiers
24834261PMC4017509What OpenQuestion holds
Registered trials
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