ReviewGastroenterology and hepatology from bed to bench2013
Clinical implications of BRAF mutation test in colorectal cancer.
Review in Gastroenterology and hepatology from bed to bench, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 27 citations in OpenAlex.
- Identification of a Subset of Stage I Colorectal Cancer Patients With High Recurrence Risk.Journal of the National Cancer Institute · 2022Article
- Screening for Colorectal Cancer Leading into a New Decade: The "Roaring '20s" for Epigenetic Biomarkers?Current oncology (Toronto, Ont.) · 2021Review
- Identification of key candidate genes and pathways associated with colorectal aberrant crypt foci-to-adenoma-to-carcinoma progression.Gastroenterology and hepatology from bed to bench · 2021Article
- Stratification and prediction of drug synergy based on target functional similarity.NPJ systems biology and applications · 2020Article
- Personalized Medicine-Current and Emerging Predictive and Prognostic Biomarkers in Colorectal Cancer.Cancers · 2020Review
- Difference Between Left-Sided and Right-Sided Colorectal Cancer: A Focused Review of Literature.Gastroenterology research · 2018Review
- DNA hypermethylation as a predictor of extramural vascular invasion (EMVI) in rectal cancer.Cancer biology & therapy · 2018Article
- Barrett's esophagus transits to a cancer condition via potential biomarkers.Gastroenterology and hepatology from bed to bench · 2018Article
- Insulin dysregulation plays a critical role in colon inflammation: a bioinformatics approach.Gastroenterology and hepatology from bed to bench · 2018Article
- Barrett's esophagus network analysis revealed that arginine, alanine, aspartate, glutamate, valine, leucine and isoleucine can be biomarkers.Gastroenterology and hepatology from bed to bench · 2018Article
- SRC and TP53 play critical role in low-grade dysplasia colorectal mucosa transformation into cancer.Gastroenterology and hepatology from bed to bench · 2018Article
- Gene expression analysis of colon high-grade dysplasia revealed new molecular mechanism of disease.Gastroenterology and hepatology from bed to bench · 2018Article
- Network analysis of grade II into grade III transition in rectum cancer patients.Gastroenterology and hepatology from bed to bench · 2018Article
- Evaluation of GKN1 and GKN2 gene expression as a biomarker of gastric cancer.Gastroenterology and hepatology from bed to bench · 2018Article
- Single-nucleotide polymorphism of Exo1 gene is associated with risk of colorectal cancer based on robust Bayesian approach.Gastroenterology and hepatology from bed to bench · 2018Article
- Metabolic analysis of acute appendicitis by using system biology approach.Gastroenterology and hepatology from bed to bench · 2018Article
- Influence of working in auto factory on gastroesophageal reflux disease.Gastroenterology and hepatology from bed to bench · 2018Article
- Evaluation of the cardiovascular risk in patients with biliary stones: a descriptive cross-sectional study.Gastroenterology and hepatology from bed to bench · 2018Article
- Iranian high risk regions due to esophageal cancer: spatial analysis of cancer registry data.Gastroenterology and hepatology from bed to bench · 2018Article
- The high frequency of esophageal disorders in Iranian patients with non-cardiac chest pain.Gastroenterology and hepatology from bed to bench · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Knowledge about the clinical significance of V-Raf Murine Sarcoma Viral Oncogene Homolog B1 (BRAF) mutations in colorectal cancer (CRC) is growing. BRAF encodes a protein kinase involved with intracellular signaling and cell division. The gene product is a downstream effector of Kirsten Ras 1(KRAS) within the RAS/RAF/MAPK cellular signaling pathway. Evidence suggests that BRAF mutations, like KRAS mutations, result in uncontrolled, non-growth factor-dependent cellular proliferation. Similar to the rationale that KRAS mutation precludes effective treatment with anti-EGFR drugs. Recently, BRAF mutation testing has been introduced into routine clinical laboratories because its significance has become clearer in terms of effect on pathogenesis of CRC, utility in differentiating sporadic CRC from Lynch syndrome (LS), prognosis, and potential for predicting patient outcome in response to targeted drug therapy. In this review we describe the impact of BRAF mutations for these aspects.
Indexed as
Identifiers
24834238PMC4017487W309052956What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.