ArticleEcancermedicalscience2014
Expression of COX-2 and bcl-2 in oral lichen planus lesions and lichenoid reactions.
Article in Ecancermedicalscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 12 citations in OpenAlex.
- Molecular Markers in Oral Lichen Planus - Insight into Pathogenesis.Head and neck pathology · 2025Article
- Analysis of Immunohistochemical Expression of Bcl-2 in Cases of Psoriasis and Psoriasiform Dermatitis.Cureus · 2024Article
- Review
- Synergistic Effects of Curcumin and 5-Fluorouracil on the Hepatocellular CarcinomaJournal of Cancer · 2020Article
- Differential metallothionein expression in oral lichen planus and amalgam-associated oral lichenoid lesions.Medicina oral, patologia oral y cirugia bucal · 2018Article
- Increased cyclooxygenase 2 expression in association with oral lichen planus severity.Journal of dental sciences · 2016Article
- Erosive oral lichen planus inflicts higher cellular stress than reticular type.Journal of oral and maxillofacial pathology : JOMFPArticle
- Expression of Ki-67, p53, α-SMA and COX-2 in lichen planus and related lesions: A pilot study.Journal of oral biology and craniofacial researchArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelledOral lichen planus and lichenoid reactions are autoimmune type inflammatory conditions of the oral mucosa with similar clinical and histological characteristics. Recent data suggest that oral lichenoid reactions (OLR) present a greater percentage of malignant transformation than oral lichen planus (OLP).
objectiveTo compare the expression of bcl-2 and COX-2 in OLP and OLR.
methodsThe study population consisted of 65 cases; 34 cases diagnosed as OLR and 31 as OLP. A retrospective study was done, and bcl-2 and COX-2 expression was semiquantitatively analysed.
resultsFifty-three per cent (18/34) of the ORL samples tested positive for COX-2, whereas in the OLP group, 81% of the samples (25/31) immunostained positive for COX-2. The Fisher's exact test for the expression of COX-2 revealed that there are significant differences between the two groups, P = 0.035. With respect to the expression of the bcl-2 protein, 76% (26/34) of the samples were positive in OLR, while 97% (30/31) were positive in the group with OLP. The Fisher's exact test for the expression of bcl-2 revealed that there are significant statistical differences between the two groups, P = 0.028.
conclusionsThe expression of bcl-2 and COX-2 was more commonly expressed in OLP when compared with OLR.
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