ArticleInternational journal of peptides2014
Cationic Bioactive Peptide from the Seeds of Benincasa hispida.
Article in International journal of peptides, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 43 citations in OpenAlex.
- Bioactive Peptides From theFood science & nutrition · 2026Review
- Antioxidant activity and cytotoxic effects of Benincasa hispida juice on HepG2 cells.BMC complementary medicine and therapies · 2026Article
- Peptides in plant-microbe interactions: Functional diversity and pharmacological applications.Cell surface (Amsterdam, Netherlands) · 2025Review
- Microbial- and Plant-Derived Bioactive Peptides and Their Applications against Foodborne Pathogens: Current Status and Future Prospects.International journal of microbiology · 2024Review
- Proteomics and Molecular Docking Analyses Reveal the Bio-Chemical and Molecular Mechanism Underlying the Hypolipidemic Activity of Nano-Liposomal Bioactive Peptides in 3T3-L1 Adipocytes.Foods (Basel, Switzerland) · 2023Article
- Bioactive Peptides: Synthesis, Sources, Applications, and Proposed Mechanisms of Action.International journal of molecular sciences · 2022Review
- The Updated Review on Plant Peptides and Their Applications in Human Health.International journal of peptide research and therapeutics · 2022Review
- A Literature-Based Update onOxidative medicine and cellular longevity · 2021Review
- Bringing New Methods to the Seed Proteomics Platform: Challenges and Perspectives.International journal of molecular sciences · 2020Review
- Biologia futura: medicinal plants-derived bioactive peptides in functional perspective-a review.Biologia futura · 2020Review
- Extraction and Characterization of Antioxidant Peptides from Fruit Residues.Foods (Basel, Switzerland) · 2020Review
- Cucurbitaceae Seed Protein Hydrolysates as a Potential Source of Bioactive Peptides with Functional Properties.BioMed research international · 2017Review
- Jaburetox: update on a urease-derived peptide.The journal of venomous animals and toxins including tropical diseases · 2017Review
- Antimicrobial peptides in 2014.Pharmaceuticals (Basel, Switzerland) · 2015Review
- Biologically active and antimicrobial peptides from plants.BioMed research international · 2015Review
- Amino acid-derived defense metabolites from plants: A potential source to facilitate novel antimicrobial development.The Journal of biological chemistryReview
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A designated bioactive peptide "Hispidalin" purified from the seeds of Benincasa hispida, which is a medicinal plant, belongs to Cucurbitaceae family. Purification was achieved by using a procedure consisting of extraction from potassium phosphate buffer followed by FPLC and HPLC steps. Based on amino acid residue, this peptide is amphipathic and basic with one net positive charge having isoelectric pH 8.1. This peptide is without sulphur containing amino acid suggesting its extended conformation lacking double bond secondary structure. The results obtained from MALDI-TOF suggested that Hispidalin is of molecular mass 5.7 KDa with 49 amino acid residues and confirmed SDS-PAGE resolved ∼ 6.0 KDa protein band. This novel and unknown peptide "Hispidalin" showed broad and potent inhibitory effects against various human bacterial and fungal pathogens; its growth inhibition was significantly comparable with commercial antibacterial and antifungal drugs. The Hispidalin at 40 μ g/mL concentration exhibited 70.8% DPPH free radical-scavenging activity and 69.5% lipid peroxide inhibition. Thus, in the present study, Hispidalin demonstrated remarkable antimicrobial and antioxidant potentials from the seeds of B. hispida.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.