ArticleFrontiers in aging neuroscience2014
Voxel-based morphometry analyses of in vivo MRI in the aging mouse lemur primate.
Article in Frontiers in aging neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 39 citations in OpenAlex.
- Resveratrol does not mimic the positive effects of calorie restriction on lifespan in Microcebus murinus.Communications biology · 2025Article
- An MR-based brain template and atlas for optical projection tomography and light sheet fluorescence microscopy in neuroscience.Frontiers in neuroscience · 2024Article
- Mean amplitude of low frequency fluctuations measured by fMRI at 11.7 T in the aging brain of mouse lemur primate.Scientific reports · 2023Article
- Transmission of amyloid-beta and tau pathologies is associated with cognitive impairments in a primate.Acta neuropathologica communications · 2021Article
- Age affects procedural paired-associates learning in the grey mouse lemur (Microcebus murinus).Scientific reports · 2021Article
- Age-related decline in executive function as a hallmark of cognitive ageing in primates: an overview of cognitive and neurobiological studies.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
- Neurobiological substrates of animal personality and cognition in a nonhuman primate (Microcebus murinus).Brain and behavior · 2020Article
- Encephalopathy induced by Alzheimer brain inoculation in a non-human primate.Acta neuropathologica communications · 2019Article
- Digital templates and brain atlas dataset for the mouse lemur primate.Data in brief · 2018Article
- Caloric restriction increases lifespan but affects brain integrity in grey mouse lemur primates.Communications biology · 2018Article
- Plasma Amyloid Is Associated with White Matter and Subcortical Alterations and Is Modulated by Age and Seasonal Rhythms in Mouse Lemur Primates.Frontiers in aging neuroscience · 2018Article
- Wake-active neurons across aging and neurodegeneration: a potential role for sleep disturbances in promoting disease.SpringerPlus · 2015Article
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Cerebral atrophy is one of the most widely brain alterations associated to aging. A clear relationship has been established between age-associated cognitive impairments and cerebral atrophy. The mouse lemur (Microcebus murinus) is a small primate used as a model of age-related neurodegenerative processes. It is the first non-human primate in which cerebral atrophy has been correlated with cognitive deficits. Previous studies of cerebral atrophy in this model were based on time consuming manual delineation or measurement of selected brain regions from magnetic resonance images (MRI). These measures could not be used to analyse regions that cannot be easily outlined such as the nucleus basalis of Meynert or the subiculum. In humans, morphometric assessment of structural changes with age is generally performed with automated procedures such as voxel-based morphometry (VBM). The objective of our work was to perform user-independent assessment of age-related morphological changes in the whole brain of large mouse lemur populations thanks to VBM. The study was based on the SPMMouse toolbox of SPM 8 and involved thirty mouse lemurs aged from 1.9 to 11.3 years. The automatic method revealed for the first time atrophy in regions where manual delineation is prohibitive (nucleus basalis of Meynert, subiculum, prepiriform cortex, Brodmann areas 13-16, hypothalamus, putamen, thalamus, corpus callosum). Some of these regions are described as particularly sensitive to age-associated alterations in humans. The method revealed also age-associated atrophy in cortical regions (cingulate, occipital, parietal), nucleus septalis, and the caudate. Manual measures performed in some of these regions were in good agreement with results from automatic measures. The templates generated in this study as well as the toolbox for SPM8 can be downloaded. These tools will be valuable for future evaluation of various treatments that are tested to modulate cerebral aging in lemurs.
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