ReviewClinical medicine insights. Gastroenterology2012
Proton Pump Inhibitor use in Hospitalized Patients: Is Overutilization Becoming a Problem?
Review in Clinical medicine insights. Gastroenterology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- Antibiotic and Nonantibiotic Drugs Associated With Clostridioides difficile Infection Risk: a Pharmacopoeia-Wide Case-Cohort Study.The Journal of infectious diseases · 2026Article
- Multimodal Intervention Assessing the Appropriateness of Acid Suppression Therapy is Associated With Reduced Prescriptions at the Time of Discharge for Hospitalized Inpatients.Hospital pharmacy · 2023Article
- Proton Pump Inhibitors Use and Increased Risk of Spontaneous Bacterial Peritonitis in Cirrhotic Patients: A Retrospective Cohort Analysis.Gastroenterology research · 2022Article
- Diagnostic Challenges ofCanadian journal of gastroenterology & hepatology · 2022Article
- Incorporation of Student Pharmacists into a Proton Pump Inhibitor Deprescribing Telehealth Program for Rural Veterans.Innovations in pharmacy · 2022Article
- Pharmacist-structured review of proton pump inhibitor utilisation in primary care: A nonrandomised control study.Malaysian family physician : the official journal of the Academy of Family Physicians of Malaysia · 2021Article
- Association of Histamine-2 Blockers and Proton-Pump Inhibitors With Delirium Development in Critically Ill Adults: A Retrospective Cohort Study.Critical care explorations · 2021Article
- Impact of a multidisciplinary quality improvement initiative to reduce inappropriate usage of stress ulcer prophylaxis in hospitalized patients.British journal of clinical pharmacology · 2020Article
- Low-Value Proton Pump Inhibitor Prescriptions Among Older Adults at a Large Academic Health System.Journal of the American Geriatrics Society · 2019Article
- Proton pump inhibitors increase the severity of hepatic encephalopathy in cirrhotic patients.World journal of hepatology · 2019Article
- In silico design of novel proton-pump inhibitors with reduced adverse effects.Frontiers of medicine · 2019Article
- The Authors Reply.Kidney international reports · 2019Article
- Increased Risk of Spontaneous Bacterial Peritonitis in Cirrhotic Patients Using Proton Pump Inhibitors.GE Portuguese journal of gastroenterology · 2019Article
- Comparison of three criteria for potentially inappropriate medications in Chinese older adults.Clinical interventions in aging · 2019Article
- Proton-pump Inhibitor Use and Fracture Risk: An Updated Systematic Review and Meta-analysis.Journal of bone metabolism · 2018Article
- Duration and dosing of Proton Pump Inhibitors associated with high incidence of chronic kidney disease in population-based cohort.PloS one · 2018Article
- Acid-Suppressive Therapy and Risk of Infections: Pros and Cons.Clinical drug investigation · 2017Review
- The Association between Proton Pump Inhibitors and Myocardial Infarction: What Do Food and Drug Administration Data Tell Us?Journal of research in pharmacy practiceArticle
- Observational
- Prescribing Pattern of Proton Pump Inhibitors in Qatar Rehabilitation Institute: A Retrospective Study.Journal of research in pharmacy practiceArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Proton pump inhibitors (PPIs) are among the most common classes of medications prescribed. Though they were previously thought of as safe, recent literature has shown risks associated with their use including increased risk for Clostridium difficile infection, pneumonia, and fractures. Due to these risks, it is important to determine if PPIs are being used appropriately. This review evaluates seven studies in hospitalized patients. Additionally, this review evaluates literature pertaining to recently discovered adverse reactions; all studies found PPIs are being overutilized. Findings highlight the importance of evaluating appropriate therapy with these agents and recommending discontinuation if a proper indication does not exist.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.