SynthesisBMJ open2014
Comparative efficacy and safety of treatments for localised prostate cancer: an application of network meta-analysis.
Synthesis in BMJ open, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- A robust Bayesian bias-adjusted random effects model for consideration of uncertainty about bias terms in evidence synthesis.Statistics in medicine · 2022Pooled it
- Abiraterone and enzalutamide had different adverse effects on the cardiovascular system: a systematic review with pairwise and network meta-analyses.Prostate cancer and prostatic diseases · 2021Pooled it
- Assessment of non-inferiority with meta-analysis: example of hypofractionated radiation therapy in breast and prostate cancer.Scientific reports · 2020Pooled it
- Primary cryotherapy for localised or locally advanced prostate cancer.The Cochrane database of systematic reviews · 2018Pooled it
- Pooled it
- Differences in treatment choices between prostate cancer patients using a decision aid and patients receiving care as usual: results from a randomized controlled trial.World journal of urology · 2021Trial
- Outpatient application of formalin for chronic rectal bleeding after prostate irradiation: a quasi-experimental study.International journal of colorectal disease · 2017Trial
- Article
- Incorporating external evidence on between-trial heterogeneity in network meta-analysis.Statistics in medicine · 2019Article
- Shared decision making for men facing prostate cancer treatment: a systematic review of randomized controlled trials.Patient preference and adherence · 2019Review
- Combined Modality Therapies for High-Risk Prostate Cancer: Narrative Review of Current Understanding and New Directions.Frontiers in oncology · 2019Review
- Reliability and validity of PROMIS measures administered by telephone interview in a longitudinal localized prostate cancer study.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2016Article
- Two new methods to fit models for network meta-analysis with random inconsistency effects.BMC medical research methodology · 2016Article
- PREDICT: model for prediction of survival in localized prostate cancer.World journal of urology · 2016Article
- Methods for calculating confidence and credible intervals for the residual between-study variance in random effects meta-regression models.BMC medical research methodology · 2014Article
- A Qualitative Study of Men's Experiences Using Navigate: A Localized Prostate Cancer Treatment Decision Aid.MDM policy & practiceArticle
- Salvage image guided radiation therapy to the prostate after cryotherapy failure.Advances in radiation oncologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
contextThere is ongoing uncertainty about the optimal management of patients with localised prostate cancer.
objectiveTo evaluate the comparative efficacy and safety of different treatments for patients with localised prostate cancer.
designSystematic review with Bayesian network meta-analysis to estimate comparative ORs, and a score (0-100%) that, for a given outcome, reflects average rank order of superiority of each treatment compared against all others, using the Surface Under the Cumulative RAnking curve (SUCRA) statistic. DATA SOURCES: Electronic searches of MEDLINE without language restriction. STUDY SELECTION: Randomised trials comparing the efficacy and safety of different primary treatments (48 papers from 21 randomised trials included 7350 men). DATA EXTRACTION: 2 reviewers independently extracted data and assessed risk of bias.
resultsComparative efficacy and safety evidence was available for prostatectomy, external beam radiotherapy (different types and regimens), observational management and cryotherapy, but not high-intensity focused ultrasound. There was no evidence of superiority for any of the compared treatments in respect of all-cause mortality after 5 years. Cryotherapy was associated with less gastrointestinal and genitourinary toxicity than radiotherapy (SUCRA: 99% and 77% for gastrointestinal and genitourinary toxicity, respectively).
conclusionsThe limited available evidence suggests that different treatments may be optimal for different efficacy and safety outcomes. These findings highlight the importance of informed patient choice and shared decision-making about treatment modality and acceptable trade-offs between different outcomes. More trial evidence is required to reduce uncertainty. Network meta-analysis may be useful to optimise the power of evidence synthesis studies once data from new randomised controlled studies in this field are published in the future.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.