ReviewThe journals of gerontology. Series A, Biological sciences and medical sciences2014
Stem cells as vehicles for youthful regeneration of aged tissues.
Review in The journals of gerontology. Series A, Biological sciences and medical sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03514537 (Use of Autologous Stem/Stromal Cellular Stromal Vascular Fraction), which is not on this map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Use of Autologous Stem/Stromal Cellular Stromal Vascular Fraction (cSVF) In Cases Of Frailty and Aging Processes Using Autologous Stem-Stromal Cell Infusion in Patients With Aging Frailty And Wellness
Who cites it
18 citing papers in PubMed, 36 citations in OpenAlex.
- Allogeneic Mesenchymal Stem Cells Ameliorate Aging Frailty: A Phase II Randomized, Double-Blind, Placebo-Controlled Clinical Trial.The journals of gerontology. Series A, Biological sciences and medical sciences · 2017Trial
- Allogeneic Human Mesenchymal Stem Cell Infusions for Aging Frailty.The journals of gerontology. Series A, Biological sciences and medical sciences · 2017Trial
- Association of TERT promoter mutations with early recurrence in hepatocellular carcinoma: a subgroup analysis in a Vietnamese cohort.BMC cancer · 2026Article
- Role of maraviroc and/or rapamycin in the liver of IL10 KO mice with frailty syndrome.PloS one · 2024Article
- Physiological Systems in Promoting Frailty.Comprehensive Physiology · 2022Review
- Regenerative Medicine for the Treatment of Ischemic Heart Disease; Status and Future Perspectives.Frontiers in cell and developmental biology · 2021Review
- Klotho Deficiency Accelerates Stem Cells Aging by Impairing Telomerase Activity.The journals of gerontology. Series A, Biological sciences and medical sciences · 2019Article
- Cell Replacement to Reverse Brain Aging: Challenges, Pitfalls, and Opportunities.Trends in neurosciences · 2018Review
- Stem Cell Transplantation for Frailty.The journals of gerontology. Series A, Biological sciences and medical sciences · 2017Review
- Local application of IGFBP5 protein enhanced periodontal tissue regeneration via increasing the migration, cell proliferation and osteo/dentinogenic differentiation of mesenchymal stem cells in an inflammatory niche.Stem cell research & therapy · 2017Article
- Head regeneration in hemichordates is not a strict recapitulation of development.Developmental dynamics : an official publication of the American Association of Anatomists · 2016Article
- From restoration to regeneration: periodontal aging and opportunities for therapeutic intervention.Periodontology 2000 · 2016Review
- Increased Adipocyte Area in Injured Muscle With Aging and Impaired Remodeling in Female Mice.The journals of gerontology. Series A, Biological sciences and medical sciences · 2016Article
- Position Paper of the European Society of Cardiology Working Group Cellular Biology of the Heart: cell-based therapies for myocardial repair and regeneration in ischemic heart disease and heart failure.European heart journal · 2016Review
- Review
- Stem Cells in Neurological Disorders: Emerging Therapy with Stunning Hopes.Molecular neurobiology · 2015Review
- Robust regeneration of adult zebrafish lateral line hair cells reflects continued precursor pool maintenance.Developmental biology · 2015Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Stem cells hold great promise for regenerative therapies for a wide spectrum of diseases and disorders of aging by virtue of their ability to regenerate tissues and contribute to their homeostasis. Aging is associated with a marked decline in these functionalities of adult stem cells. As such, regeneration of aged tissues is both less efficient and less effective than that of young tissues. Recent studies have revealed the remarkably dynamic responses of stem cells to systemic signals, including the ability of "youthful" factors in the blood of young animals to enhance the functionality of aged stem cells. Thus, there is much hope that even aged stem cells retain a remarkable regenerative potential if provided with the correct cues and environment to engage in tissue repair. The overall focus of the presentations of this session is to address the determinants of changes in stem cell functionality with age, the key characteristics of stem cells in aged tissues, the extent to which those characteristics are capable of being rejuvenated and by what signals, and the potential for stem cell therapeutics for chronic diseases and acute injuries in aged individuals.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.