ArticleScience (New York, N.Y.)2014
Neurosensory perception of environmental cues modulates sperm motility critical for fertilization.
Article in Science (New York, N.Y.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 53 citations in OpenAlex.
- Mating strategies in Caenorhabditis elegans populations are determined by male developmental history.G3 (Bethesda, Md.) · 2026Article
- In Vitro Effect of Elevated Ammonia and Urea Levels on Post-Thawed Bull Semen Sperm Characteristics.Veterinary sciences · 2025Article
- Assessing genetic conservation of human sociability-linked genes in C. elegans.Behavior genetics · 2025Article
- Transmembrane protein 120A (TMEM-120A/TACAN) coordinates with PIEZO channel during Caenorhabditis elegans reproductive regulation.G3 (Bethesda, Md.) · 2023Article
- A Fiji protocol for analyzing puncta is a robust tool for measuring GLR-1::GFP accumulation in the ventral nerve cord ofmicroPublication biology · 2023Article
- Cyclooxygenase-2 deficiency attenuates lipopolysaccharide-induced inflammation, apoptosis, and acute lung injury in adult mice.American journal of physiology. Regulatory, integrative and comparative physiology · 2022Article
- Sperm-Guiding Unconventional Prostaglandins inMetabolites · 2021Review
- Neuronal regulatedeLife · 2021Article
- Mechanisms of TGFß in prostaglandin synthesis and sperm guidance in Caenorhabditis elegans.Developmental dynamics : an official publication of the American Association of Anatomists · 2021Article
- Chemosensory signal transduction in Caenorhabditis elegans.Genetics · 2021Review
- Similar sequences but dissimilar biological functions of GDF11 and myostatin.Experimental & molecular medicine · 2020Review
- Article
- Article
- Article
- Signature profile of cyclooxygenase-independent F2 series prostaglandins in C. elegans and their role in sperm motility.Scientific reports · 2019Article
- Measuring Sperm Guidance and Motility within the Caenorhabditis elegans Hermaphrodite Reproductive Tract.Journal of visualized experiments : JoVE · 2019Article
- Natural products as chemical tools to dissect complex biology in C. elegans.Current opinion in chemical biology · 2019Review
- A primer on pheromone signaling in Caenorhabditis elegans for systems biologists.Current opinion in systems biology · 2019Article
- Genetic Contributions to Ectopic Sperm Cell Migration inG3 (Bethesda, Md.) · 2018Article
- Comprehensive profiling of prostaglandins in human ovarian follicular fluid using mass spectrometry.Prostaglandins & other lipid mediators · 2018Article
Corrections and comments
- Commented on by
Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
Environmental exposures affect gamete function and fertility, but the mechanisms are poorly understood. Here, we show that pheromones sensed by ciliated neurons in the Caenorhabditis elegans nose alter the lipid microenvironment within the oviduct, thereby affecting sperm motility. In favorable environments, pheromone-responsive sensory neurons secrete a transforming growth factor-β ligand called DAF-7, which acts as a neuroendocrine factor that stimulates prostaglandin-endoperoxide synthase [cyclooxygenase (Cox)]-independent prostaglandin synthesis in the ovary. Oocytes secrete F-class prostaglandins that guide sperm toward them. These prostaglandins are also synthesized in Cox knockout mice, raising the possibility that similar mechanisms exist in other animals. Our data indicate that environmental cues perceived by the female nervous system affect sperm function.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.