ArticleJournal of magnetic resonance imaging : JMRI2015
Molecular origin of a loading-induced black layer in the deep region of articular cartilage at the magic angle.
Article in Journal of magnetic resonance imaging : JMRI, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Low-beta frequency band neurofeedback training: effects on attentional orientation, executive control, and underlying neural mechanisms.Behavioral and brain functions : BBF · 2026Article
- Detecting Collagen Fiber Architecture after Destabilization of the Medial Meniscus Surgery Using High-Resolution Diffusion Tensor Imaging.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2026Article
- High angular resolution diffusion imaging (HARDI) of porcine menisci: a comparison of diffusion tensor imaging and generalized q-sampling imaging.Quantitative imaging in medicine and surgery · 2024Article
- Magic angle effect on diffusion tensor imaging in ligament and brain.Magnetic resonance imaging · 2022Article
- Resolution-dependent influences of compressed sensing in quantitative T2 mapping of articular cartilage.NMR in biomedicine · 2020Article
- Characterization complex collagen fiber architecture in knee joint using high-resolution diffusion imaging.Magnetic resonance in medicine · 2020Article
- Magnetic resonance imaging (MRI) studies of knee joint under mechanical loading: Review.Magnetic resonance imaging · 2020Review
- Article
- Quantitative measurement of T2, T1ρ and T1 relaxation times in articular cartilage and cartilage-bone interface by SE and UTE imaging at microscopic resolution.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2018Article
- Compressed sensing in quantitative determination of GAG concentration in cartilage by microscopic MRI.Magnetic resonance in medicine · 2018Article
- MAPS - a Magic Angle Positioning System for Enhanced Imaging in High-Field Small-Bore MRI.Journal of medical robotics research · 2016Article
- MRI properties of a unique hypo-intense layer in degraded articular cartilage.Physics in medicine and biology · 2015Article
- Effects of cryopreservation on the depth-dependent elastic modulus in articular cartilage and implications for osteochondral grafting.Journal of biomechanical engineering · 2015Article
- Detection of early osteoarthritis in canine knee joints 3 weeks post ACL transection by microscopic MRI and biomechanical measurement.Journal of orthopaedic surgery (Hong Kong)Article
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4 authors.
Funding
Abstract
purposeTo investigate the molecular origin of an unusual low-intensity layer in the deep region of articular cartilage as seen in magnetic resonance imaging (MRI) when the tissue is imaged under compression and oriented at the magic angle. MATERIALS AND
methodsMicroscopic MRI (μMRI) T2 and T1 ρ experiments were carried out on 18 specimens, both native and degraded (treated with trypsin). The glycosaminoglycan (GAG) concentrations in the specimens were quantified by both sodium ICP-OES and μMRI Gd(DTPA)(2-) -contrast methods. The mechanical modulus of the specimens was also measured.
resultsNative tissue shows no load-induced layer, while the trypsin-degraded tissue shows clearly the low-intensity line at the deep part of tissue. The GAG reductions were confirmed by the sodium ICP-OES (from 81.7 ± 5.4 mg/mL to 9.2 ± 3.4 mg/mL), MRI GAG quantification (from 72.4 ± 6.7 mg/mL to 11.2 ± 2.9 mg/mL). The modulus reduction was confirmed by biomechanics (from 4.3 ± 0.7 MPa to 0.3 ± 0.1 MPa).
conclusionBoth T2 and T1 ρ profiles in native and degraded cartilage show strongly strain-, depth-, and angle-dependence using high-resolution MRI. The GAG reduction is responsible for the visualization of a low-intensity layer in deep cartilage when it is loaded and oriented at 55°.
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