ArticleInsect biochemistry and molecular biology2014
Metabolic analysis reveals changes in the mevalonate and juvenile hormone synthesis pathways linked to the mosquito reproductive physiology.
Article in Insect biochemistry and molecular biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 53 citations in OpenAlex.
- Juvenile hormone induces phosphorylation of insulin/insulin-like growth factor signaling proteins in previtellogenic Aedes aegypti mosquitoes.Insect science · 2025Article
- Investigating the role of aae-miR-34-5p in the regulation of juvenile hormone biosynthesis genes in the mosquito Aedes aegypti.Scientific reports · 2023Article
- Current Status of Omics Studies Elucidating the Features of Reproductive Biology in Blood-Feeding Insects.Insects · 2023Review
- Widely Targeted HPLC-MS/MS Metabolomics Analysis Reveals Natural Metabolic Insights in Insects.Metabolites · 2023Article
- Differential gene expression underlying the biosynthesis of Dufour's gland signals inCurrent research in insect science · 2023Article
- Genetics tools for corpora allata specific gene expression in Aedes aegypti mosquitoes.Scientific reports · 2022Article
- Article
- Steroid hormone ecdysone deficiency stimulates preparation for photoperiodic reproductive diapause.PLoS genetics · 2021Article
- Inhibition of juvenile hormone synthesis in mosquitoes by the methylation inhibitor 3-deazaneplanocin A (DZNep).Insect biochemistry and molecular biology · 2019Article
- Juvenile hormone controls ovarian development in female Anopheles albimanus mosquitoes.Scientific reports · 2019Article
- Juvenile Hormone III but Not 20-Hydroxyecdysone Regulates the Embryonic Diapause ofFrontiers in physiology · 2019Article
- Omics approaches to study juvenile hormone synthesis.Current opinion in insect science · 2018Review
- JH biosynthesis and hemolymph titers in adult male Aedes aegypti mosquitoes.Insect biochemistry and molecular biology · 2018Article
- Local Juvenile Hormone activity regulates gut homeostasis and tumor growth in adult Drosophila.Scientific reports · 2017Article
- Juvenile hormone biosynthesis in adult Blattella germanica requires nuclear receptors Seven-up and FTZ-F1.Scientific reports · 2017Article
- Article
- Fast, ultra-trace detection of juvenile hormone III from mosquitoes using mass spectrometry.Talanta · 2016Article
- Article
- A corpora allata farnesyl diphosphate synthase in mosquitoes displaying a metal ion dependent substrate specificity.Insect biochemistry and molecular biology · 2015Article
- 20-Hydroxyecdysone stimulation of juvenile hormone biosynthesis by the mosquito corpora allata.Insect biochemistry and molecular biology · 2015Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Juvenile hormone (JH) regulates reproductive maturation in insects; therefore interruption of JH biosynthesis has been considered as a strategy for the development of target-specific insecticides. The corpora allata (CA) from mosquitoes is highly specialized to supply variable levels of JH, which are linked to ovarian developmental stages and influenced by nutritional signals. However, very little is known about how changes in JH synthesis relate to reproductive physiology and how JH synthesis regulation is translated into changes in the CA machinery. With the advent of new methods that facilitate the analysis of transcripts, enzymes and metabolites in the minuscule CA, we were able to provide comprehensive descriptions of the mevalonic (MVA) and JH synthesis pathways by integrating information on changes in the basic components of those pathways. Our results revealed remarkable dynamic changes in JH synthesis and exposed part of a complex mechanism that regulates CA activity. Principal component (PC) analyses validated that both pathways (MVAP and JH-branch) are transcriptionally co-regulated as a single unit, and catalytic activities for the enzymes of the MVAP and JH-branch also changed in a coordinate fashion. Metabolite studies showed that global fluctuations in the intermediate pool sizes in the MVAP and JH-branch were often inversely related. PC analyses suggest that in female mosquitoes, there are at least 4 developmental switches that alter JH synthesis by modulating the flux at distinctive points in both pathways.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.