Evidence map›Paper›PMID 24833226›Full record

ArticleBiology2013

Dynamic programming used to align protein structures with a spectrum is robust.

Allen Holder, Jacqueline Simon, Jonathon Strauser, Jonathan Taylor, Yosi Shibberu

Abstract read
In one paragraph

Article in Biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Allen HolderDepartment of Mathematics, Rose-Hulman Institute of Technology, Terre Haute, IN 47803, USA. holder@rose-hulman.edu.
Jacqueline SimonDepartment of Mathematics, Rose-Hulman Institute of Technology, Terre Haute, IN 47803, USA. simonjc@rose-hulman.edu.
Jonathon StrauserRoche Diagnostics, Indianapolis, IN 46256, USA. strauserj@upmc.edu.
Jonathan TaylorDepartment of Mathematics, Rose-Hulman Institute of Technology, Terre Haute, IN 47803, USA. taylorj7@rose-hulman.edu.
Yosi ShibberuDepartment of Mathematics, Rose-Hulman Institute of Technology, Terre Haute, IN 47803, USA. shibberu@rose-hulman.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Several efficient algorithms to conduct pairwise comparisons among large databases of protein structures have emerged in the recent literature. The central theme is the design of a measure between the Cα atoms of two protein chains, from which dynamic programming is used to compute an alignment. The efficiency and efficacy of these algorithms allows large-scale computational studies that would have been previously impractical. The computational study herein shows that the structural alignment algorithm eigen-decomposition alignment with the spectrum (EIGAs) is robust against both parametric and structural variation.

Identifiers

PMID24833226
PMCPMC4009789

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.