ArticleBioEssays : news and reviews in molecular, cellular and developmental biology2014
Disruption of daily rhythms in gene expression: the importance of being synchronised.
Article in BioEssays : news and reviews in molecular, cellular and developmental biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed.
- Social Jetlag and Prostate Cancer Incidence in Alberta's Tomorrow Project: A Prospective Cohort Study.Cancers · 2020Article
- Timing of eating in adults across the weight spectrum: Metabolic factors and potential circadian mechanisms.Physiology & behavior · 2018Review
- Antimicrobial capacity of the freshwater planarians against S. aureus is under the control of Timeless.Virulence · 2017Article
- Circadian Kinetics of Cell Cycle Progression in Adult Neurogenic Niches of a Diurnal Vertebrate.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Sleep, circadian dysrhythmia, obesity and diabetes.World journal of diabetes · 2016Review
- Orexin signaling regulates both the hippocampal clock and the circadian oscillation of Alzheimer's disease-risk genes.Scientific reports · 2016Article
- Reciprocal interactions between circadian clocks and aging.Mammalian genome : official journal of the International Mammalian Genome Society · 2016Review
Corrections and comments
- Comment on
Authors and funding
2 authors.
Funding
Abstract
Extending a normal 24 hours day by four hours is unexpectedly highly disruptive to daily rhythms in gene expression in the blood. Using a paradigm in which human subjects were exposed to a 28 hours day, Archer and colleagues show how this sleep-altering forced desynchrony protocol caused complex disruption to daily rhythms in distinct groups of genes. Such perturbations in the temporal organisation of the blood transcriptome arise quickly, and point to the fragile nature of coordinated genomic activity. Chronic disruption of the daily and circadian rhythms in sleep compromise health and well-being and this study reveals potential new molecular targets to combat the disruptive effects of shift work and jetlag.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.