ArticlePlant cell reports2014
Methyl jasmonate represses growth and affects cell cycle progression in cultured Taxus cells.
Article in Plant cell reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 70 citations in OpenAlex.
- Elicitation and scale-up of Bacopa saponin production by plant cell suspension culture in stirred tank bioreactor.Bioprocess and biosystems engineering · 2026Article
- Analysis genome of Pseudotaxus chienii reveals insights into the origin and evolution of taxane biosynthesis.Nature communications · 2025Article
- Genome-Wide Characterization of thePlants (Basel, Switzerland) · 2025Article
- Harnessing Jasmonate Pathways: PgJAR1's Impact on Ginsenoside Accumulation in Ginseng.Plants (Basel, Switzerland) · 2025Article
- 3,5-DCQA as a Major Molecule in MeJA-TreatedBiomolecules · 2024Article
- Article
- The interplay between cell wall integrity and cell cycle progression in plants.Plant molecular biology · 2023Review
- Exploring the Interplay between Metabolic Pathways and Taxane Production in ElicitedPlants (Basel, Switzerland) · 2023Article
- Cyclodextrins Increase Triterpene Production inPlants (Basel, Switzerland) · 2022Article
- The Interface amongst Conserved and Specialized Pathways in Non-Paclitaxel and Paclitaxel AccumulatingMetabolites · 2021Article
- Effects of Abiotic Elicitors on Expression and Accumulation of Three Candidate Benzophenanthridine Alkaloids in Cultured Greater Celandine Cells.Molecules (Basel, Switzerland) · 2021Article
- PlantFrontiers in plant science · 2021Review
- Jasmonic acid and methyl jasmonate modulate growth, photosynthetic activity and expression of photosystem II subunit genes in Brassica oleracea L.Scientific reports · 2020Article
- Plant tissue culture as a perpetual source for production of industrially important bioactive compounds.Biotechnology reports (Amsterdam, Netherlands) · 2020Review
- Time-dependent behavior of phenylpropanoid pathway in response to methyl jasmonate in Scrophularia striata cell cultures.Plant cell reports · 2020Article
- Cell Suspensions ofMolecules (Basel, Switzerland) · 2019Article
- Transcriptome analyses provide insights into the expression pattern and sequence similarity of several taxol biosynthesis-related genes in three Taxus species.BMC plant biology · 2019Article
- Comparison of elicitor-based effects on metabolic responses of Taxus × media hairy roots in perfluorodecalin-supported two-phase culture system.Plant cell reports · 2019Article
- COI1-dependent jasmonate signalling affects growth, metabolite production and cell wall protein composition in arabidopsis.Annals of botany · 2018Article
- Effect of salicylic acid and methyl jasmonate in the production of phenolic compounds in plant cell suspension cultures ofBiotechnology reports (Amsterdam, Netherlands) · 2018Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
key messageMethyl jasmonate elicitation of Taxus cultures enhances paclitaxel accumulation, but represses growth by inhibition of cell cycle progression. Growth repression is evident both at the culture level and transcriptional level. Methyl jasmonate (MeJA) elicitation is an effective strategy to induce and enhance synthesis of the anticancer agent paclitaxel (Taxol(®)) in Taxus cell suspension cultures; however, concurrent decreases in growth are often observed, which is problematic for large-scale bioprocessing. Here, increased accumulation of paclitaxel in Taxus cuspidata suspension cultures with MeJA elicitation was accompanied by a concomitant decrease in cell growth, evident within the first 3 days post-elicitation. Both MeJA-elicited and mock-elicited cultures exhibited similar viability with no apoptosis up to day 16 and day 24 of the cell culture period, respectively, suggesting that growth repression is not attributable to cell death. Flow cytometric analyses demonstrated that MeJA perturbed cell cycle progression of asynchronously dividing Taxus cells. MeJA slowed down cell cycle progression, impaired the G1/S transition as observed by an increase in G0/G1 phase cells, and decreased the number of actively dividing cells. Through a combination of deep sequencing and gene expression analyses, the expression status of Taxus cell cycle-associated genes correlated with observations at the culture level. Results from this study provide valuable insight into the mechanisms governing MeJA perception and subsequent events leading to repression of Taxus cell growth.
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Registered trials
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