Evidence map›Paper›PMID 24832443›Full record

ArticleCell host & microbe2014

Iron ERRs with Salmonella.

Ferric C Fang, Günter Weiss

Abstract readComment
In one paragraph

Article in Cell host & microbe, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Estrogen and bacterial infection.Frontiers in immunology · 2025
    Review
  2. Article
  3. Clofazimine Reduces the Survival ofACS infectious diseases · 2020
    Article
  4. Article
  5. Review
  6. Bacterial iron-sulfur cluster sensors in mammalian pathogens.Metallomics : integrated biometal science · 2015
    Review
  7. Review
  8. Iron at the interface of immunity and infection.Frontiers in pharmacology · 2014
    Review
  9. Gut microbes
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Ferric C FangDepartments of Laboratory Medicine and Microbiology, University of Washington, Seattle, WA 98195-7735, USA. Electronic address: fcfang@uw.edu.
Günter WeissDepartment of Internal Medicine VI, Infectious Diseases, Immunology, Rheumatology, and Pneumology, Medical University of Innsbruck, 6020 Innsbruck, Austria.

Funding

THE SALMONELLA TYPHIMURIUM SIGMAE REGULONR01AI044486 · NIAID · UNIVERSITY OF WASHINGTON · PI FANG, FERRIC C · 1999 to 2016
$4.9M
NITRIC OXIDE CYTOTOXICITY IN SALMONELLOSISR01AI039557 · NIAID · UNIVERSITY OF WASHINGTON · PI FANG, FERRIC C · 1997 to 2012
$4.1M
INTERDISCIPLINARY PROGRAM IN BACTERIAL PATHOGENESIST32AI055396 · NIAID · UNIVERSITY OF WASHINGTON · PI FANG, FERRIC C · 2003 to 2019
$2.8M
Silencing and Counter-Silencing of Salmonella Virulence GenesR01AI101084 · NIAID · UNIVERSITY OF WASHINGTON · PI FANG, FERRIC C · 2012 to 2015
$1.5M
Iron Homeostasis in Salmonella-Host InteractionsR01AI077629 · NIAID · UNIVERSITY OF WASHINGTON · PI FANG, FERRIC C · 2009 to 2010
$780k
MECHANISMS OF NITRIC OXIDE CYTOTOXICITY IN SALMONELLOSISR21AI039557 · NIAID · UNIVERSITY OF COLORADO DENVER · PI FANG, FERRIC C · 1996 to 1996
–
NIAID NIH HHS AI101084NIAID NIH HHS AI39557NIAID NIH HHS AI55396NIAID NIH HHS R01 AI039557NIAID NIH HHS R01 AI044486NIAID NIH HHS R01 AI077629NIAID NIH HHS R01 AI101084NIAID NIH HHS T32 AI055396
6 · The paper itself

Abstract

The hormone hepcidin promotes iron sequestration by macrophages. A recent study by Kim et al. (2014) implicates the orphan receptor ERRγ (estrogen-related receptor γ) in the regulation of hepcidin production and suggests that targeting the ERRγ-hepcidin axis may be beneficial during infection with the facultative intracellular pathogen Salmonella.

Indexed as

Salmonella typhimuriumAnimalsHepatocytesHepcidinsInterleukin-6IronMacrophagesReceptors, EstrogenSalmonella InfectionsSignal TransductionHepcidinsInterleukin-6IronReceptors, Estrogen

Identifiers

PMID24832443
PMCPMC4049527

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.