ArticleThe Journal of chemical physics2014
Pathway structure determination in complex stochastic networks with non-exponential dwell times.
Article in The Journal of chemical physics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- High-order Michaelis-Menten equations allow inference of hidden kinetic parameters in enzyme catalysis.Nature communications · 2025Article
- Direct detection of molecular intermediates from first-passage times.Science advances · 2020Article
- Fixation times in differentiation and evolution in the presence of bottlenecks, deserts, and oases.Journal of theoretical biology · 2015Article
- Single-molecule modeling of mRNA degradation by miRNA: Lessons from data.BMC systems biology · 2015Article
- Stochastic kinetics on networks: when slow is fast.The journal of physical chemistry. B · 2014Article
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Authors and funding
3 authors.
Funding
Abstract
Analysis of complex networks has been widely used as a powerful tool for investigating various physical, chemical, and biological processes. To understand the emergent properties of these complex systems, one of the most basic issues is to determine the structure and topology of the underlying networks. Recently, a new theoretical approach based on first-passage analysis has been developed for investigating the relationship between structure and dynamic properties for network systems with exponential dwell time distributions. However, many real phenomena involve transitions with non-exponential waiting times. We extend the first-passage method to uncover the structure of distinct pathways in complex networks with non-exponential dwell time distributions. It is found that the analysis of early time dynamics provides explicit information on the length of the pathways associated to their dynamic properties. It reveals a universal relationship that we have condensed in one general equation, which relates the number of intermediate states on the shortest path to the early time behavior of the first-passage distributions. Our theoretical predictions are confirmed by extensive Monte Carlo simulations.
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