ArticlePLoS genetics2014
Meiotic drive impacts expression and evolution of x-linked genes in stalk-eyed flies.
Article in PLoS genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 52 citations in OpenAlex.
- Single-cell consequences of X-linked meiotic drive in stalk-eyed flies.PLoS genetics · 2025Article
- The metabolic costs of meiotic drive.Proceedings. Biological sciences · 2025Article
- Unraveling the role of satellite DNAs in the evolution of the giant XY sex chromosomes of the flea beetle Omophoita octoguttata (Coleoptera, Chrysomelidae).BMC biology · 2025Article
- Impacts of Sex Ratio Meiotic Drive on Genome Structure and Function in a Stalk-Eyed Fly.Genome biology and evolution · 2023Article
- Article
- Supergene potential of a selfish centromere.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
- Sheltering of deleterious mutations explains the stepwise extension of recombination suppression on sex chromosomes and other supergenes.PLoS biology · 2022Article
- Novel patterns of expression and recruitment of new genes on theProceedings. Biological sciences · 2022Article
- Beyond Drosophila: resolving the rapid radiation of schizophoran flies with phylotranscriptomics.BMC biology · 2021Article
- Resistance to natural and synthetic gene drive systems.Journal of evolutionary biology · 2020Review
- Extensive Recombination Suppression and Epistatic Selection Causes Chromosome-Wide Differentiation of a Selfish Sex Chromosome inGenetics · 2020Article
- Effects of a male meiotic driver on male and female transcriptomes in the house mouse.Proceedings. Biological sciences · 2019Article
- Meiotic drive reduces egg-to-adult viability in stalk-eyed flies.Proceedings. Biological sciences · 2019Article
- Ejaculate sperm number compensation in stalk-eyed flies carrying a selfish meiotic drive element.Heredity · 2019Article
- A fast-evolving X-linked duplicate of importin-α2 is overexpressed in sex-ratio drive in Drosophila neotestacea.Molecular ecology · 2018Article
- Unexpected patterns of segregation distortion at a selfish supergene in the fire ant Solenopsis invicta.BMC genetics · 2018Article
- Viral discovery and diversity in trypanosomatid protozoa with a focus on relatives of the human parasiteProceedings of the National Academy of Sciences of the United States of America · 2018Article
- Contrasting patterns of X-chromosome divergence underlie multiple sex-ratio polymorphisms in stalk-eyed flies.Journal of evolutionary biology · 2017Article
- Spermatogenesis Drives Rapid Gene Creation and Masculinization of the X Chromosome in Stalk-Eyed Flies (Diopsidae).Genome biology and evolution · 2016Article
- Twenty-Five New Viruses Associated with the Drosophilidae (Diptera).Evolutionary bioinformatics online · 2016Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although sex chromosome meiotic drive has been observed in a variety of species for over 50 years, the genes causing drive are only known in a few cases, and none of these cases cause distorted sex-ratios in nature. In stalk-eyed flies (Teleopsis dalmanni), driving X chromosomes are commonly found at frequencies approaching 30% in the wild, but the genetic basis of drive has remained elusive due to reduced recombination between driving and non-driving X chromosomes. Here, we used RNAseq to identify transcripts that are differentially expressed between males carrying either a driving X (XSR) or a standard X chromosome (XST), and found hundreds of these, the majority of which are X-linked. Drive-associated transcripts show increased levels of sequence divergence (dN/dS) compared to a control set, and are predominantly expressed either in testes or in the gonads of both sexes. Finally, we confirmed that XSR and XST are highly divergent by estimating sequence differentiation between the RNAseq pools. We found that X-linked transcripts were often strongly differentiated (whereas most autosomal transcripts were not), supporting the presence of a relatively large region of recombination suppression on XSR presumably caused by one or more inversions. We have identified a group of genes that are good candidates for further study into the causes and consequences of sex-chromosome drive, and demonstrated that meiotic drive has had a profound effect on sequence evolution and gene expression of X-linked genes in this species.
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