ArticleTransplantation2014
Mannitol infusion within 15 min of cross-clamp improves living donor kidney preservation.
Article in Transplantation, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 27 citations in OpenAlex.
- Mannitol for prevention of acute kidney injury after liver transplantation: a randomized controlled trial.BMC anesthesiology · 2022Trial
- Prospective assessment of the impact of intraoperative diuretics in kidney transplant recipient surgery.Canadian journal of surgery. Journal canadien de chirurgieTrial
- Impact of Mannitol Administration on Postoperative Renal Function After Robot-Assisted Partial Nephrectomy.Journal of clinical medicine · 2024Article
- Clinical Outcomes Associated with Degree of Hypernatremia in Neurocritically Ill Patients.Journal of Korean Neurosurgical Society · 2023Article
- Preservation solutions for attenuation of ischemia-reperfusion injury in vascularized composite allotransplantation.SAGE open medicine · 2021Article
- Increasing metformin concentrations and its excretion in both rat and porcine ex vivo normothermic kidney perfusion model.BMJ open diabetes research & care · 2020Article
- Examining Mannitol Use in Kidney Cancer Surgery: A Cautionary Tale of Extrapolated Surgical Data.European urology focus · 2019Article
- Use of Mannitol for Ischemia Reperfusion Injury in Kidney Transplant and Partial Nephrectomies-Review of Literature.Current urology reports · 2019Review
- Perianesthetic Management of Laparoscopic Kidney Surgery.Current urology reports · 2018Review
- Optical coherence tomography and computer-aided diagnosis of a murine model of chronic kidney disease.Journal of biomedical optics · 2017Article
- Observational
- Canadian survey on the rates of use of intraoperative diuretics and justification for their use during renal allograft reperfusion.Canadian journal of surgery. Journal canadien de chirurgieArticle
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundOptical coherence tomography (OCT) revealed that cells lining proximal convoluted tubules of living donor kidneys (LDKs) procured by laparoscopic procedures were very swollen in response to the brief period of ischemia experienced between the time of arterial vessel clamping and flushing the excised kidney with cold preservation solution. Damage to the tubules as a result of this cell swelling resulted in varying degrees of acute tubular necrosis (ATN) that slowed the recovery of the donor kidneys during the first 2 weeks after their transplantation.
methodsTo prevent this cell damage during LDK procurement, we changed the protocol for intravenous administration of mannitol (i.e., 12.5 or 25 g) to the donor. Specifically, we reduced the time of mannitol administration from 30 to 15 min or less before clamping the renal artery.
resultOCT revealed that this change in the timing of mannitol administration protected the human donor proximal tubules from normothermic-induced cell swelling. An evaluation of posttransplant recovery of renal function showed that patients treated with this modified protocol returned to normal renal function significantly faster than those treated with mannitol 30 min or more before clamping the renal artery.
conclusionBecause slow graft recovery in the first weeks after transplantation represents a risk factor for long-term graft function and survival, we believe that this change in pretreatment protocol will improve renal transplants in patients receiving LDK.
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Registered trials
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