ReviewCytotherapy2014
Stem cell-based biological pacemakers from proof of principle to therapy: a review.
Review in Cytotherapy, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 32 citations in OpenAlex.
- Single-cell transcriptome analysis reveals CD34 as a marker of human sinoatrial node pacemaker cardiomyocytes.Nature communications · 2024Article
- Shenfu injection: a review of pharmacological effects on cardiovascular diseases.Frontiers in pharmacology · 2024Review
- Local tissue mechanics control cardiac pacemaker cell embryonic patterning.Life science alliance · 2023Article
- Assembly of the Cardiac Pacemaking Complex: Electrogenic Principles of Sinoatrial Node Morphogenesis.Journal of cardiovascular development and disease · 2021Review
- Guide Cells Support Muscle Regeneration and Affect Neuro-Muscular Junction Organization.International journal of molecular sciences · 2021Article
- Shenfu Injection: A Famous Chinese Prescription That PromotesEvidence-based complementary and alternative medicine : eCAM · 2021Article
- Article
- Cardiac and neuronal HCN channelopathies.Pflugers Archiv : European journal of physiology · 2020Review
- Adipose‑derived stem cells overexpressing SK4 calcium‑activated potassium channel generate biological pacemakers.International journal of molecular medicine · 2019Article
- Canine and human sinoatrial node: differences and similarities in the structure, function, molecular profiles, and arrhythmia.Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology · 2019Review
- A Brief History of Pacemaking.Frontiers in physiology · 2019Review
- Dynamic Cellular Integration Drives Functional Assembly of the Heart's Pacemaker Complex.Cell reports · 2018Article
- Transcription factor TBX18 promotes adult rat bone mesenchymal stem cell differentiation to biological pacemaker cells.International journal of molecular medicine · 2018Article
- Transcription factor Tbx18 induces the differentiation of c-kitAmerican journal of translational research · 2018Article
- TBX18 gene induces adipose-derived stem cells to differentiate into pacemaker-like cells in the myocardial microenvironment.International journal of molecular medicine · 2016Article
- Probing the Electrophysiology of the Developing Heart.Journal of cardiovascular development and disease · 2016Review
- Fibrous scaffolds for building hearts and heart parts.Advanced drug delivery reviews · 2016Review
- Modern stem cell therapy: approach to disease.Wiener klinische Wochenschrift · 2015Review
- State of the art of leadless pacing.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Electronic pacemakers are the standard therapy for bradycardia-related symptoms but have shortcomings. Over the past 15 years, experimental evidence has demonstrated that gene and cell-based therapies can create a biological pacemaker. Recently, physiologically acceptable rates have been reported with an adenovirus-based approach. However, adenovirus-based protein expression does not last more than 4 weeks, which limits its clinical applicability. Cell-based platforms are potential candidates for longer expression. Currently there are two cell-based approaches being tested: (i) mesenchymal stem cells used as a suitcase for delivering pacemaker genes and (ii) pluripotent stem cells differentiated down a cardiac lineage with endogenous pacemaker activity. This review examines the current achievements in engineering a biological pacemaker, defines the patient population for whom this device would be useful and identifies the challenges still ahead before cell therapy can replace current electronic devices.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.