Evidence map›Paper›PMID 24831687›Full record

ArticlePloS one2014

Association between secreted phosphoprotein-1 (SPP1) polymorphisms and low bone mineral density in women.

Jen-Hau Chen, Yen-Ching Chen, Chien-Lin Mao, Jeng-Min Chiou, Chwen Keng Tsao, Keh-Sung Tsai

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact, top 94% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Review
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  4. Genomic structural variations link multiple genes to bone mineral density in a multi-ethnic cohort study: Louisiana osteoporosis study.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2024
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4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Jen-Hau ChenDepartment of Geriatrics and Gerontology, National Taiwan University Hospital, No. 1, Taipei, Taiwan; Department of Internal Medicine, National Taiwan University Hospital, No. 7, Taipei, Taiwan; Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.
Yen-Ching ChenInstitute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.
Chien-Lin MaoInstitute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.
Jeng-Min ChiouInstitute of Statistical Science, Academia Sinica, Nankang, Taipei, Taiwan.
Chwen Keng TsaoMJ Health Management Institution, 12F., No. 413, Section 4, Taipei, Taiwan.
Keh-Sung TsaiDepartment of Geriatrics and Gerontology, National Taiwan University Hospital, No. 1, Taipei, Taiwan; Department of Internal Medicine, National Taiwan University Hospital, No. 7, Taipei, Taiwan; Department of Laboratory Medicine, National Taiwan University Hospital, No. 7, Taipei, Taiwan.
National Taiwan University · TWNational Taiwan University Hospital · TWInstitute of Statistical Science, Academia Sinica · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundA recent meta-analysis found that secreted phosphoprotein-1 (SPP1) can predict the risk of both osteoporosis and fracture. No study has explored the association of SPP1 haplotype-tagging single nucleotide polymorphisms (htSNPs) and haplotypes with bone mineral density (BMD).

methodsThis is a cross-sectional study. A total of 1,313 healthy Taiwanese women aged 40 to 55 years were recruited from MJ Health Management Institute from 2009 to 2010. BMD was dichotomized into high and low BMD groups. Three common (allele frequency ≥5%) htSNPs were selected to examine the association between sequence variants of SPP1 and BMD.

resultsHomozygosity for the T allele of rs4754 were protective from low BMD [TT vs. CC: adjusted OR (AOR)  = 0.58, 95% confidence interval (CI)  = 0.83-0.89]. A protective effect was also found for women carrying 2 copies of Hap3 TCT (AOR  = 0.57, 95% CI  = 0.34-0.95). Menopausal status marginally interacted with SPP1 rs6839524 on BMD (p = 0.049). Postmenopausal women carrying variant rs6839524 (GG+GC vs. CC: AOR  = 2.35, 95% CI  = 1.06-5.20) or Hap1 TGC (AOR  = 2.36, 95% CI  = 1.06-5.24) were associated with 2.4-fold risk of low BMD. For women with low BMI (<18.5 kg/m2), variant rs6839524 (AOR  = 7.64) and Hap1 (AOR  = 6.42) were associated with increased risk of low BMD. These findings did not reach statistical significance after correction for multiple tests.

conclusionsSPP1 htSNP protected against low BMD in middle-aged women. SPP1 genetic markers may be important for the prediction of osteoporosis at an early age.

Indexed as

Polymorphism, GeneticPolymorphism, Single NucleotideAdultAllelesBody Mass IndexBone DensityCross-Sectional StudiesFemaleHaplotypesHomozygoteHumansMenopauseMiddle AgedOsteopontinOsteoporosisSurveys and QuestionnairesOsteopontinSPP1 protein, human

Identifiers

PMID24831687
PMCPMC4022728
OpenAlexW1969146785

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.