ArticleJornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia
Mycobacterium tuberculosis resistance to antituberculosis drugs in Mozambique.
Article in Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed, 11 citations in OpenAlex.
- Risk factors associated with multidrug-resistant pulmonary tuberculosis in patients over 15 years old: a retrospective case-control study.Frontiers in tuberculosis · 2025Article
- Evaluation of the frequency of resistance to 2 drugs (Isoniazid and Rifampin) by molecular investigation and it's risk factors in new cases of smear positive pulmonary tuberculosis in health centers under the cover of Jundishapur University of Medical Sciences in 2017.Journal of family medicine and primary care · 2020Article
- Mozambique field epidemiology and laboratory training program: a pathway for strengthening human resources in applied epidemiology.The Pan African medical journal · 2017Article
- Drug-resistant tuberculosis in Central Mozambique: the role of a rapid genotypic susceptibility testing.BMC infectious diseases · 2016Article
- Map the gap: missing children with drug-resistant tuberculosis.Public health action · 2015Article
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Authors and funding
5 authors at 1 institution in 1 country.
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Abstract
objectiveTo determine the drug resistance profile of Mycobacterium tuberculosis in Mozambique.
methodsWe analyzed secondary data from the National Tuberculosis Referral Laboratory, in the city of Maputo, Mozambique, and from the Beira Regional Tuberculosis Referral Laboratory, in the city of Beira, Mozambique. The data were based on culture-positive samples submitted to first-line drug susceptibility testing (DST) between January and December of 2011. We attempted to determine whether the frequency of DST positivity was associated with patient type or provenance.
resultsDuring the study period, 641 strains were isolated in culture and submitted to DST. We found that 374 (58.3%) were resistant to at least one antituberculosis drug and 280 (43.7%) were resistant to multiple antituberculosis drugs. Of the 280 multidrug-resistant tuberculosis cases, 184 (65.7%) were in previously treated patients, most of whom were from southern Mozambique. Two (0.71%) of the cases of multidrug-resistant tuberculosis were confirmed to be cases of extensively drug-resistant tuberculosis. Multidrug-resistant tuberculosis was most common in males, particularly those in the 21-40 year age bracket.
conclusionsM. tuberculosis resistance to antituberculosis drugs is high in Mozambique, especially in previously treated patients. The frequency of M. tuberculosis strains that were resistant to isoniazid, rifampin, and streptomycin in combination was found to be high, particularly in samples from previously treated patients.
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