ReviewCurrent topics in microbiology and immunology2014
Helper T cell plasticity: impact of extrinsic and intrinsic signals on transcriptomes and epigenomes.
Review in Current topics in microbiology and immunology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed.
- Aiolos promotes CXCR3 expression on Th1 cells via positive regulation of IFN-γ/STAT1 signaling.JCI insight · 2024Article
- Plasticity and lineage commitment of individual TScience advances · 2024Article
- TCR-CD3 signal strength regulates plastic coexpression of IL-4 and IFN-γ in Tfh-like cells.Frontiers in immunology · 2024Article
- Eos Promotes TH2 Differentiation by Interacting with and Propagating the Activity of STAT5.Journal of immunology (Baltimore, Md. : 1950) · 2023Article
- Human CCR6+ Th Cells Show Both an Extended Stable Gradient of Th17 Activity and Imprinted Plasticity.Journal of immunology (Baltimore, Md. : 1950) · 2023Article
- Human CCR6bioRxiv : the preprint server for biology · 2023Article
- The Interplay of Transcription and Genome Topology Programs T Cell Development and Differentiation.Journal of immunology (Baltimore, Md. : 1950) · 2022Article
- Signaling networks controlling ID and E protein activity in T cell differentiation and function.Frontiers in immunology · 2022Review
- Mapping the landscape of chromatin dynamics during naïve CD4+ T-cell activation.Scientific reports · 2021Article
- Cytokine-regulated Th17 plasticity in human health and diseases.Immunology · 2021Review
- Evasion of Immunological Memory byFrontiers in immunology · 2021Review
- Rapid Enhancer Remodeling and Transcription Factor Repurposing Enable High Magnitude Gene Induction upon Acute Activation of NK Cells.Immunity · 2020Article
- Transcriptomic Profiling of Human Effector and Regulatory T Cell Subsets Identifies Predictive Population Signatures.ImmunoHorizons · 2020Article
- Ambiguous roles and potential therapeutic strategies of innate lymphoid cells in different types of tumor.Oncology letters · 2020Review
- Quorum sensing via dynamic cytokine signaling comprehensively explains divergent patterns of effector choice among helper T cells.PLoS computational biology · 2020Article
- Immune cell diversity contributes to the pathogenesis of myocarditis.Heart failure reviews · 2019Review
- Epigenetic regulation of T helper cells and intestinal pathogenicity.Seminars in immunopathology · 2019Review
- Imbalance of Circulating Innate Lymphoid Cell Subpopulations in Patients With Septic Shock.Frontiers in immunology · 2019Article
- Do Memory CD4 T Cells Keep Their Cell-Type Programming: Plasticity versus Fate Commitment? T-Cell Heterogeneity, Plasticity, and Selection in Humans.Cold Spring Harbor perspectives in biology · 2018Review
- Molecular mechanisms underlying Th1-like Treg generation and function.Cellular and molecular life sciences : CMLS · 2017Review
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
CD4(+) helper T cells are crucial for autoimmune and infectious diseases; however, the recognition of the many, diverse fates available continues unabated. Precisely what controls specification of helper T cells and preserves phenotypic commitment is currently intensively investigated. In this review, we will discuss the major factors that impact helper T cell fate choice, ranging from cytokines and the microbiome to metabolic control and epigenetic regulation. We will also discuss the technological advances along with the attendant challenges presented by "big data," which allow the understanding of these processes on comprehensive scales.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.