ArticlePloS one2014
Enterococcus faecalis from healthy infants modulates inflammation through MAPK signaling pathways.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
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Who cites it
56 citing papers in PubMed, 99 citations in OpenAlex.
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- Insights into ecology, pathogenesis, and biofilm formation ofMicrobiology and molecular biology reviews : MMBR · 2025Review
- Effects ofAnimals : an open access journal from MDPI · 2025Article
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- Gonadal sex and chromosome complement influence the gut microbiome in a mouse model of allergic airway inflammation.Physiological genomics · 2024Article
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- Influence of neo-adjuvant radiotherapy on the intestinal microbiota of rectal cancer patients.Journal of cancer research and clinical oncology · 2023Article
- Anti-inflammatory and wound healing properties of lactic acid bacteria and its peptides.Folia microbiologica · 2023Review
- Phytate Hydrolysate Differently Modulates the Immune Response of Human Healthy and Cancer Colonocytes to Intestinal Bacteria.Nutrients · 2022Article
- Danshensu alleviates pseudo-typed SARS-CoV-2 induced mouse acute lung inflammation.Acta pharmacologica Sinica · 2022Article
- Review
- The pathogenesis of prevalent aerobic bacteria in aerobic vaginitis and adverse pregnancy outcomes: a narrative review.Reproductive health · 2022Review
- Effect of the Microbiome on Intestinal Innate Immune Development in Early Life and the Potential Strategy of Early Intervention.Frontiers in immunology · 2022Review
- Gut Microbiota and Metabolome Description of Antibiotic-Treated Neonates From Parturients With Intrauterine Infection.Frontiers in cellular and infection microbiology · 2022Article
- NFrontiers in genetics · 2022Article
- Pathways and microbiome modifications related to surgery and enterocolitis in Hirschsprung disease.Pediatric surgery international · 2022Article
- Complementary Food Ingredients Alter Infant Gut Microbiome Composition and Metabolism In Vitro.Microorganisms · 2021Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Colonizing commensal bacteria after birth are required for the proper development of the gastrointestinal tract. It is believed that bacterial colonization pattern in neonatal gut affects gut barrier function and immune system maturation. Studies on the development of faecal microbiota in infants showed that the neonatal gut was first colonized with enterococci followed by other microbiota such as Bifidobacterium. Other studies showed that babies who developed allergy were less often colonized with Enterococcus during the first month of life as compared to healthy infants. Many studies have been conducted to elucidate how bifidobacteria or lactobacilli, some of which are considered probiotic, regulate infant gut immunity. However, fewer studies have been focused on enterococi. In our study, we demonstrate that E. faecalis, isolated from healthy newborns, suppress inflammatory responses activated in vivo and in vitro. We found E. faecalis attenuates proinflammatory cytokine secretions, especially IL-8, through JNK and p38 signaling pathways. This finding shed light on how the first colonizer, E.faecalis, regulates inflammatory responses in the host.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.