Evidence map›Paper›PMID 24830712›Full record

ReviewMolecules (Basel, Switzerland)2014

Issues and prospects of microRNA-based biomarkers in blood and other body fluids.

John R Chevillet, Inyoul Lee, Hilary A Briggs, Yuqing He, Kai Wang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Molecules (Basel, Switzerland), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
73citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

73 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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13 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

John R ChevilletInstitute for Systems Biology, Seattle, WA 98109, USA.
Inyoul LeeInstitute for Systems Biology, Seattle, WA 98109, USA.
Hilary A BriggsLaboratory of the Biology of Addictive Diseases, Rockefeller University, New York, NY 10065, USA.
Yuqing HeInstitute of Medical Systems Biology, Guangdong Medical College, Dongguan, Guangdong 523808, China. dr.hyq@hotmail.com.
Kai WangInstitute for Systems Biology, Seattle, WA 98109, USA. kwang@systemsbiology.org.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cell-free circulating microRNAs (miRNAs) in the blood are good diagnostic biomarker candidates for various physiopathological conditions, including cancer, neurodegeneration, diabetes and other diseases. Since their discovery in 2008 as blood biomarkers, the field has expanded rapidly with a number of important findings. Despite the initial optimistic views of their potential for clinical application, there are currently no circulating miRNA-based diagnostics in use. In this article, we review the status of circulating miRNAs, examine different analytical approaches, and address some of the challenges and opportunities.

Indexed as

Biomarkers, TumorBody FluidsHumansMicroRNAsNeoplasmsBiomarkers, TumorMicroRNAs

Identifiers

PMID24830712
PMCPMC6271291

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.