ArticleScientific reports2014
Labeling of neuronal differentiation and neuron cells with biocompatible fluorescent nanodiamonds.
Article in Scientific reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 78 citations in OpenAlex.
- Functionalized Nanodiamonds for Targeted Neuronal Electromagnetic Signal Detection.ACS applied materials & interfaces · 2024Article
- Dynamics for High-Sensitivity Detection of Free Radicals in Primary Bronchial Epithelial Cells upon Stimulation with Cigarette Smoke Extract.Nano letters · 2024Article
- Advances of Fluorescent Nanodiamond Platforms for Intracellular and On-Chip Biosensing.Biosensors · 2024Review
- Fluorescence-Based Mono- and Multimodal Imaging for In Vivo Tracking of Mesenchymal Stem Cells.Biomolecules · 2023Review
- Fluorescent Nanodiamonds for Tracking Single Polymer Particles in Cells and Tissues.Analytical chemistry · 2023Article
- Intracellular Relaxometry, Challenges, and Future Directions.ACS central science · 2022Review
- Nanoscale Diamond-Based Formulation as an Immunomodulator and Potential Therapeutic for Lymphoma.Frontiers in pharmacology · 2022Article
- Review
- A quantum thermometric sensing and analysis system using fluorescent nanodiamonds for the evaluation of living stem cell functions according to intracellular temperature.Nanoscale advances · 2020Article
- 3D tomographic magnetofluorescence imaging of nanodiamonds.Biomedical optics express · 2020Article
- Nanodiamonds with powerful ability for drug delivery and biomedical applications: Recent updates on in vivo study and patents.Journal of pharmaceutical analysis · 2020Review
- Nanoparticle-based Cell Trackers for Biomedical Applications.Theranostics · 2020Review
- Knockdown of microRNA-135b in Mammary Carcinoma by Targeted Nanodiamonds: Potentials and Pitfalls of In Vivo Applications.Nanomaterials (Basel, Switzerland) · 2019Article
- Artificial neural networks enabled by nanophotonics.Light, science & applications · 2019Article
- Recent review of the effect of nanomaterials on stem cells.RSC advances · 2018Review
- Nanodiamonds-induced effects on neuronal firing of mouse hippocampal microcircuits.Scientific reports · 2018Article
- Nanodiamonds facilitate killing of intracellular uropathogenic E. coli in an in vitro model of urinary tract infection pathogenesis.PloS one · 2018Article
- Multifunctional nanodiamonds in regenerative medicine: Recent advances and future directions.Journal of controlled release : official journal of the Controlled Release Society · 2017Review
- Delivery of Fluorescent Nanoparticles to the Brain.Journal of molecular neuroscience : MN · 2016Review
- STED imaging of green fluorescent nanodiamonds containing nitrogen-vacancy-nitrogen centers.Biomedical optics express · 2016Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nanodiamond is a promising carbon nanomaterial developed for biomedical applications. Here, we show fluorescent nanodiamond (FND) with the biocompatible properties that can be used for the labeling and tracking of neuronal differentiation and neuron cells derived from embryonal carcinoma stem (ECS) cells. The fluorescence intensities of FNDs were increased by treatment with FNDs in both the mouse P19 and human NT2/D1 ECS cells. FNDs were taken into ECS cells; however, FNDs did not alter the cellular morphology and growth ability. Moreover, FNDs did not change the protein expression of stem cell marker SSEA-1 of ECS cells. The neuronal differentiation of ECS cells could be induced by retinoic acid (RA). Interestingly, FNDs did not affect on the morphological alteration, cytotoxicity and apoptosis during the neuronal differentiation. Besides, FNDs did not alter the cell viability and the expression of neuron-specific marker β-III-tubulin in these differentiated neuron cells. The existence of FNDs in the neuron cells can be identified by confocal microscopy and flow cytometry. Together, FND is a biocompatible and readily detectable nanomaterial for the labeling and tracking of neuronal differentiation process and neuron cells from stem cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.