ArticlePloS one2014
Identification of a novel enterovirus E isolates HY12 from cattle with severe respiratory and enteric diseases.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
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Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.
- A systematic review of evidence that enteroviruses may be zoonotic.Emerging microbes & infections · 2018Pooled it
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- Combined use of dill essential oil and tannic acid creates stage-specific, and time-dependent antiviral effect against bovine viral pathogens (BoHV-1, BVDV, BPIV-3, BRSV, and BEV).Veterinary research communications · 2026Article
- Isolation and partial 5'UTR-based molecular characterization of bovine enterovirus F from non-diarrheic cattle in Türkiye.Molecular biology reports · 2026Article
- Isolation and identification of a genotype F bovine enterovirus in western China.Microbiology spectrum · 2026Article
- Detection and molecular characterization of bovine enterovirus E2 from dairy calves with respiratory disease in Urumqi, Xinjiang, China.Frontiers in cellular and infection microbiology · 2026Article
- Molecular characterization of ten viral pathogens causing calf diarrhea in Hanwoo (Bos Taurus coreanae) by next generation sequencing.BMC veterinary research · 2025Article
- Genomic Characterization of Two Bovine Enterovirus Strains Isolated from Newly Transported Cattle.Veterinary sciences · 2025Article
- Inhibition of Bovine Enterovirus Infection by Magnolol via Modulating the Gut Microbiota in Mice.Viruses · 2025Article
- Enterovirus E infections in goats with respiratory disease.BMC veterinary research · 2025Article
- BEV 2C protein inhibits the NF-κB signalling pathway to promote viral replication by targeting IKBKB and p65.Veterinary research · 2025Article
- Identification of a new bovine picornavirus (Journal of veterinary science · 2024Article
- Article
- GRP78 recognizes EV-F 3D protein and activates NF-κB to repress virus replication by interacting with CHUK/IKBKB.Journal of virology · 2024Article
- Genetic diversity and recombination of bovine enterovirus strains in China.Microbiology spectrum · 2024Article
- Enterovirus E infects bovine peripheral blood mononuclear cells. Implications for pathogenesis?Journal of veterinary research · 2023Article
- A Neonatal Murine Model for Caprine Enterovirus Infection and the Viral Tissue Tropism.Viruses · 2023Article
- A multiplex real-time fluorescence-based quantitative PCR assay for calf diarrhea viruses.Frontiers in microbiology · 2023Article
- Establishment and application of multiplex droplet digital polymerase chain reaction assay for bovine enterovirus, bovine coronavirus, and bovine rotavirus.Frontiers in veterinary science · 2023Article
- Antiviral Effect of Bovine Lactoferrin against Enterovirus E.Molecules (Basel, Switzerland) · 2022Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study, a virus strain designated as HY12 was isolated from cattle with a disease of high morbidity and mortality in Jilin province. Biological and physiochemical properties showed that HY12 isolates is cytopathic with an extremely high infectivity. HY12 is resistant to treatment of organic solvent and acid, and unstable at 60°C for 1 h. Electron microscopy observation revealed the virus is an approximately 22-28 nm in diameter. The complete genome sequence of HY12 consists of 7416 nucleotides, with a typical picornavirus genome organization including a 5'-untranslated region (UTR), a large single ORF encoding a polyprotein of 2176 amino acids, and a 3'-UTR. Phylogenetic analysis clustered HY12 isolates to a new serotype/genotype within the clade of enterovirus E (formerly BEV-A). Alignment analysis revealed a unique insertion of 2 amino acid residues (NF) at the C-terminal of VP1 protein between aa 825 and 826, and several rare mutations in VP1 and VP4 of HY12 isolates in relation to known bovine enterovirus (BEV) strains. This is the first report of an enterovirus E in China, which is potentially associated with an outbreak in cattle with severe respiratory and enteric diseases.
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