Trial reportIndian journal of pediatrics2015
Isotonic intravenous maintenance fluid reduces hospital acquired hyponatremia in young children with central nervous system infections.
Trial report in Indian journal of pediatrics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 3 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- Efficacy and safety of isotonic versus hypotonic intravenous maintenance fluids in hospitalized children: an updated systematic review and meta-analysis of randomized controlled trials.Pediatric nephrology (Berlin, Germany) · 2024Pooled it
- ESPNIC clinical practice guidelines: intravenous maintenance fluid therapy in acute and critically ill children- a systematic review and meta-analysis.Intensive care medicine · 2022Pooled it
- Isotonic versus hypotonic solutions for maintenance intravenous fluid administration in children.The Cochrane database of systematic reviews · 2014Pooled it
- Hyponatremia after pediatric surgery: Randomized trial of fluid composition on antidiuretic hormone response.Pediatric research · 2026Trial
- Isotonic versus Hypotonic Parenteral Maintenance Fluids in Very Severe Pneumonia.Indian journal of pediatrics · 2016Trial
- The Clinical and Metabolic Derangements after Using 0.9% Normal Saline as Maintenance Intravenous Fluid in Children.Annals of African medicine · 2026Article
- Correction: ESPNIC clinical practice guidelines: intravenous maintenance fluid therapy in acute and critically ill children- a systematic review and meta-analysis.Intensive care medicine · 2023Article
- Korean Society of Nephrology 2022 recommendations on controversial issues in diagnosis and management of hyponatremia.The Korean journal of internal medicine · 2022Review
- Korean Society of Nephrology 2022 Recommendations on controversial issues in diagnosis and management of hyponatremia.Kidney research and clinical practice · 2022Article
- Korean Society of Nephrology 2022 Recommendations on Controversial Issues in Diagnosis and Management of Hyponatremia.Electrolyte & blood pressure : E & BP · 2022Review
- Efficacy and Safety of Isotonic and Hypotonic Intravenous Maintenance Fluids in Hospitalised Children: A Systematic Review and Meta-Analysis of Randomised Controlled Trials.Children (Basel, Switzerland) · 2021Article
- Clinical Management of Patients with Dengue Infection in Japan: Results from National Database of Health Insurance Claims.The American journal of tropical medicine and hygiene · 2020Article
- Article
- Maintenance intravenous fluids for children with central nervous system infections.Indian journal of pediatrics · 2015Article
- Impact of perioperative hyponatremia in children: A narrative review.World journal of critical care medicine · 2014Review
- Management of hyponatremia in various clinical situations.Current treatment options in neurology · 2014Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo find the appropriate type of intravenous fluid (isotonic vs. hypotonic saline in 5 % dextrose) for empiric maintenance fluid therapy in children with central nervous system (CNS) infections that reduces the incidence of hospital acquired hyponatremia.
methodsThis blinded randomized controlled trial included hospitalized children aged 3 mo to 5 y with suspected CNS infections requiring intravenous maintenance fluid for at least 24 h. The subjects were randomized to receive 0.9 % saline (Group-A), 0.45 % saline (Group-B) and 0.18 % saline (Group-C) at standard maintenance rate. The outcome measures were proportion of patients developing hyponatremia (serum sodium < 135 mmol/L) after 24 h and serum sodium values at 6, 12, 18, 24 h of receiving maintenance fluids.
resultsOf the 92 patients enrolled, 31, 30 and 31 patients were randomized to Group A, B and C, respectively. Majority (60.7 %) of the patients in Group-C developed hyponatremia compared with 7.1 % of the children in Group-A and 46.1 % in Group-B. During first 24 h of fluid administration successive fall in the serum sodium values was observed in patients receiving hypotonic fluids. The risk of developing hyponatremia was nearly 6½ (95 % confidence interval (CI) 1.6-26) to 8.5 (95 % CI 2.16-33.39) times more in patients who received hypotonic saline compared to those who received isotonic saline.
conclusionsAdministration of 0.9 % saline in 5 % dextrose as intravenous maintenance fluid in children with CNS infection leads to significantly less incidence of hyponatremia when compared to that with hypotonic fluids.
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