ArticlePloS one2014
High resolution T1ρ mapping of in vivo human knee cartilage at 7T.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- MRI T2 and T1ρ relaxation in patients at risk for knee osteoarthritis: a systematic review and meta-analysis.BMC musculoskeletal disorders · 2019Pooled it
- Alterations in whole muscle quality and physiological cross-sectional area measured with quantitative MRI following ACL injury.Journal of translational medicine · 2025Article
- Novel spin-lock time sampling strategies for improved reproducibility in quantitative T1ρ mapping.NMR in biomedicine · 2024Article
- Quantitative susceptibility and T1Osteoarthritis and cartilage open · 2024Article
- Cartilage compositional MRI-a narrative review of technical development and clinical applications over the past three decades.Skeletal radiology · 2024Review
- AcidoCEST-UTE MRI Reveals an Acidic Microenvironment in Knee Osteoarthritis.International journal of molecular sciences · 2022Article
- T1ρ imaging as a non-invasive assessment of collagen remodelling and organization in human skeletal muscle after ligamentous injury.The Journal of physiology · 2021Article
- A pilot study to assess the healing of meniscal tears in young adult goats.Scientific reports · 2021Article
- Musculoskeletal MR Imaging Applications at Ultra-High (7T) Field Strength.Magnetic resonance imaging clinics of North America · 2021Review
- Musculoskeletal MRI at 7 T: do we need more or is it more than enough?European radiology experimental · 2020Review
- Uncompromised MRI of knee cartilage while incorporating sensitive sodium MRI.NMR in biomedicine · 2019Article
- Arthroscopic treatment of osteochondral knee defects with resorbable biphasic synthetic scaffold: clinical and radiological results and long-term survival analysis.International orthopaedics · 2019Article
- Magnetic Resonance Imaging of the Musculoskeletal System at 7T: Morphological Imaging and Beyond.Topics in magnetic resonance imaging : TMRI · 2019Review
- A unique anisotropic RMagnetic resonance in medicine · 2019Article
- Review
- Simultaneous bilateral-knee MR imaging.Magnetic resonance in medicine · 2018Article
- High quality three-dimensional gagCEST imaging of in vivo human knee cartilage at 7 Tesla.Magnetic resonance in medicine · 2017Article
- Volumetric multislice gagCEST imaging of articular cartilage: Optimization and comparison with T1rho.Magnetic resonance in medicine · 2017Article
- Fast and Quantitative T1ρ-weighted Dynamic Glucose Enhanced MRI.Scientific reports · 2017Article
- Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 3 countries.
Funding
Abstract
purposeSpin lattice relaxation time in rotating frame (T1ρ) mapping of human knee cartilage has shown promise in detecting biochemical changes during osteoarthritis. Due to higher field strength, MRI at 7T has advantages in term of SNR compared to clinical MR scanners and this can be used to increase in image resolution. Objective of current study was to evaluate the feasibility of high resolution T1ρ mapping of in vivo human knee cartilage at 7T MR scanner. MATERIALS AND
methodsIn this study we have used a T1ρ prepared GRE pulse sequence for obtaining high resolution (in plan resolution = 0.2 mm2) T1ρ MRI of human knee cartilage at 7T. The effect of a global and localized reference frequency and reference voltage setting on B0, B1 and T1ρ maps in cartilage was evaluated. Test-retest reliability results of T1ρ values from asymptomatic subjects as well as T1ρ maps from abnormal cartilage of two human subjects are presented. These results are compared with T1ρ MRI data obtained from 3T.
resultsOur approach enabled acquisition of 3D-T1ρ data within allowed SAR limits at 7T. SNR of cartilage on T1ρ weighted images was greater than 90. Off-resonance effects present in the cartilage B0, B1 and T1ρ maps obtained using global shim and reference frequency and voltage setting, were reduced by the proposed localized reference frequency and voltage setting. T1ρ values of cartilage obtained with the localized approach were reproducible. Abnormal knee cartilage showed elevated T1ρ values in affected regions. T1ρ values at 7T were significantly lower (p<0.05) compared to those obtained at 3T.
conclusionIn summary, by using proposed localized frequency and voltage setting approach, high-resolution 3D-T1ρ maps of in vivo human knee cartilage can be obtained in clinically acceptable scan times (<30 min) and SAR constraints, which provides the ability to characterize cartilage molecular integrity.
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