ArticleScientific reports2014
Design principles of stripe-forming motifs: the role of positive feedback.
Article in Scientific reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Robustness and innovation in synthetic genotype networks.Nature communications · 2023Article
- Cooperative stability renders protein complex formation more robust and controllable.Scientific reports · 2022Article
- Elucidating multi-input processing 3-node gene regulatory network topologies capable of generating striped gene expression patterns.PLoS computational biology · 2022Article
- Fixed Point Attractor Theory Bridges Structure and Function inFrontiers in neuroscience · 2022Article
- Patterning, From Conifers to Consciousness: Turing's Theory and Order From Fluctuations.Frontiers in cell and developmental biology · 2022Review
- Precise determination of input-output mapping for multimodal gene circuits using data from transient transfection.PLoS computational biology · 2020Article
- Spatiotemporal control of gene expression boundaries using a feedforward loop.Developmental dynamics : an official publication of the American Association of Anatomists · 2020Article
- Synthetic circuits reveal how mechanisms of gene regulatory networks constrain evolution.Molecular systems biology · 2018Article
- Endocytosis as a stabilizing mechanism for tissue homeostasis.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- A strategy for effective latent HIV reactivation using subtherapeutic drug doses.Scientific reports · 2017Article
- Design Principles of Biological Oscillators through Optimization: Forward and Reverse Analysis.PloS one · 2016Article
- Dynamics of gene circuits shapes evolvability.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- A unified design space of synthetic stripe-forming networks.Nature communications · 2014Article
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Authors and funding
4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Interpreting a morphogen gradient into a single stripe of gene-expression is a fundamental unit of patterning in early embryogenesis. From both experimental data and computational studies the feed-forward motifs stand out as minimal networks capable of this patterning function. Positive feedback within gene networks has been hypothesised to enhance the sharpness and precision of gene-expression borders, however a systematic analysis has not yet been reported. Here we set out to assess this hypothesis, and find an unexpected result. The addition of positive-feedback can have different effects on two different designs of feed-forward motif- it increases the parametric robustness of one design, while being neutral or detrimental to the other. These results shed light on the abundance of the former motif and especially of mutual-inhibition positive feedback in developmental networks.
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