ArticlePloS one2014
Entacapone reduces cortical activation in Parkinson's disease with wearing-off: a f-MRI study.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 14 citations in OpenAlex.
- Memantine for the patients with mild cognitive impairment in Parkinson's disease: a pharmacological fMRI study.BMC neurology · 2022Trial
- Levodopa in Parkinson's Disease: Current Status and Future Developments.Current neuropharmacology · 2018Review
- Levodopa-induced plasticity: a double-edged sword in Parkinson's disease?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Review
- Effect of entacapone on colon motility and ion transport in a rat model of Parkinson's disease.World journal of gastroenterology · 2015Article
- Eryptosis as a marker of Parkinson's disease.Aging · 2014Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeWearing-off is one of the most frequent problems encountered by levodopa-treated patients. Entacapone, a peripheral inhibitor of catechol-O-methyltransferase (COMT), reduces this motor complication by prolonging the effect of levodopa. We sought to understand the impact of COMT-inhibition on movement execution in PD patients with wearing-off by comparing functional magnetic resonance imaging (f-MRI) activation patterns prior to and during entacapone treatment. Our hypothesis was to determine whether changes in cortical activation are associated to COMT-inhibitor treatment.
methodsNine levodopa-treated non-demented PD patients with wearing-off were prospectively studied in two f-MRI session, prior to and during entacapone treatment. A group of control subjects were also studied for comparison.
resultsThe patients significantly improved under COMT-inhibitor treatment based on home diaries. F-MRI results showed that at baseline the patients presented a bilateral activation of the primary motor, controlateral premotor cortex and supplementary motor area, as well as ipsilateral cerebellum. During treatment with entacapone, PD patients showed reductions in the activations of these cortical areas and a decreased activation in the ipsilateral cerebellum.
conclusionsOur preliminary findings indicate that f-MRI is able to detect cortical activation changes during long-term modulation of dopaminergic treatment in PD patients with wearing-off, and thus, this technique could be further investigated in advanced PD patients.
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