ArticleJournal of diabetes research2014
Ketosis onset type 2 diabetes had better islet β-cell function and more serious insulin resistance.
Article in Journal of diabetes research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 18 citations in OpenAlex.
- Serum 25-hydroxyvitamin D levels and their association with ketosis in patients with newly diagnosed type 2 diabetes.Medicine · 2026Article
- The value of serum creatinine-to-cystatin C ratio in newly diagnosed ketosis-prone diabetes.Endocrine connections · 2026Article
- Differentiating diabetes type in children and adolescents with ketosis or ketoacidosis at onset: a retrospective analysis of clinical and biochemical markers.BMC endocrine disorders · 2025Article
- Article
- Abnormal insulin metabolism and decreased levels of mindfulness in type 2 diabetes mellitus.Diabetology & metabolic syndrome · 2025Article
- A Cross-Sectional Study of Atherosclerosis in Newly Diagnosed Patients with Ketosis-Prone Type 2 Diabetes.Diabetes, metabolic syndrome and obesity : targets and therapy · 2022Article
- Prevalence and Gender Differences of Metabolic Syndrome in Young Ketosis-Prone Type 2 Diabetic Individuals: A Retrospective Study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2020Article
- Initial management of diabetic ketoacidosis and prognosis according to diabetes type: a French multicentre observational retrospective study.Annals of intensive care · 2019Article
- Prevalence and clinical characteristics of hypertension and metabolic syndrome in newly diagnosed patients with ketosis-onset diabetes: a cross-sectional study.Diabetology & metabolic syndrome · 2019Article
- Hyperketonemia and ketosis increase the risk of complications in type 1 diabetes.Free radical biology & medicine · 2016Review
- Characteristics of Type 2 Diabetes with Ketosis in Baoshan, Yunnan of China.Journal of diabetes research · 2016Article
- Hyperketonemia (acetoacetate) upregulates NADPH oxidase 4 and elevates oxidative stress, ICAM-1, and monocyte adhesivity in endothelial cells.Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology · 2015Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diabetic ketosis had been identified as a characteristic of type 1 diabetes mellitus (T1DM), but now emerging evidence has identified that they were diagnosed as T2DM after long time follow up. This case control study was aimed at comparing the clinical characteristic, β-cell function, and insulin resistance of ketosis and nonketotic onset T2DM and providing evidence for treatment selection. 140 cases of newly diagnosed T2DM patients were divided into ketosis (62 cases) and nonketotic onset group (78 cases). After correction of hyperglycemia and ketosis with insulin therapy, plasma C-peptide concentrations were measured at 0, 0.5, 1, 2, and 3 hours after 75 g glucose oral administration. Area under the curve (AUC) of C-peptide was calculated. Homoeostasis model assessment was used to estimate basal β-cell function (HOMA-β) and insulin resistance (HOMA-IR). Our results showed that ketosis onset group had higher prevalence of nonalcoholic fatty liver disease (NAFLD) than nonketotic group (P = 0.04). Ketosis onset group had increased plasma C-peptide levels at 0 h, 0.5 h, and 3 h and higher AUC(0-0.5), AUC₀₋₁, AUC₀₋₃ (P < 0.05). Moreover, this group also had higher HOMA-β and HOMA-IR than nonketotic group (P < 0.05). From these data, we concluded that ketosis onset T2DM had better islet β-cell function and more serious insulin resistance than nonketotic onset T2DM.
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