ArticleJournal of diabetes research2014
Impaired β cell function in Chinese newly diagnosed type 2 diabetes mellitus with hyperlipidemia.
Article in Journal of diabetes research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 29 citations in OpenAlex.
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- Disturbed Lipid Metabolism in Diabetic Patients with Manifest Coronary Artery Disease Is Associated with Enhanced Inflammation.International journal of environmental research and public health · 2021Article
- Effect of hypertriglyceridemia in dyslipidemia-induced impaired glucose tolerance and sex differences in dietary features associated with hypertriglyceridemia among the Japanese population: The Gifu Diabetes Study.Journal of diabetes investigation · 2021Article
- Hypoglycemic, antidyslipidemic and antioxydant effects ofMetabolism open · 2021Article
- Evaluation of Antidiabetic Properties of the Leaves Extract ofTheScientificWorldJournal · 2021Article
- Glucose, lipid and oxidative stress lowering activity of the aqueous extract from leafy stems ofJournal of diabetes and metabolic disorders · 2020Article
- Hypoglycemic activity of the ethyl acetate extract fromIranian journal of basic medical sciences · 2020Article
- Evaluation of skin absorption of theJournal of diabetes and metabolic disorders · 2020Article
- The antidiabetic and hepatoprotective effects of myricitrin on aged mice with D-galactose.Gastroenterology and hepatology from bed to bench · 2020Article
- Renoprotective effect of JinQi-JiangTang tablet on high-fat diet and low-dose streptozotocin-induced type 2 diabetic rats.RSC advances · 2018Article
- Centella asiatica enhances hepatic antioxidant status and regulates hepatic inflammatory cytokines in type 2 diabetic rats.Pharmaceutical biology · 2017Article
- Effects of hydroalcoholic extract ofResearch in pharmaceutical sciences · 2017Article
- Metformin ameliorates diabetic nephropathy in a rat model of low-dose streptozotocin-induced diabetes.Experimental and therapeutic medicine · 2017Article
- Article
- PPARα Agonist Fenofibrate Reduced the Secreting Load of β-Cells in Hypertriglyceridemia Patients with Normal Glucose Tolerance.PPAR research · 2016Article
- Over-nutrient environment during both prenatal and postnatal development increases severity of islet injury, hyperglycemia, and metabolic disorders in the offspring.Journal of physiology and biochemistry · 2015Article
- Clinical characteristics and beta cell function in Chinese patients with newly diagnosed type 2 diabetes mellitus with different levels of serum triglyceride.BMC endocrine disorders · 2015Article
- Obese first-degree relatives of patients with type 2 diabetes with elevated triglyceride levels exhibit increased β-cell function.Metabolic syndrome and related disorders · 2015Article
- Antidiabetic, hypolipidemic and hepatoprotective effects ofAvicenna journal of phytomedicineArticle
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The objective is to explore the effects of hyperlipidemia on β cell function in newly diagnosed type 2 diabetes mellitus (T2DM). 208 patients were enrolled in the study and were divided into newly diagnosed T2DM with hyperlipidemia (132 patients) and without hyperlipidemia (76 patients). Demographic data, glucose levels, insulin levels, lipid profiles, homeostasis model assessment for β cell function index (HOMA-β ), homeostasis model assessment for insulin resistance index (HOMA-IR), and quantitative insulin-sensitivity check index (QUICKI) were compared between the two groups. We found that comparing with those of normal lipid levels, the subjects of newly diagnosed T2DM with hyperlipidemia were younger, and had declined HOMA-β . However, the levels of HOMA-β were comparable regardless of different lipid profiles (combined hyperlipidemia, hypertriglyceridemia, and hypercholesterolemia). Multiple stepwise linear regression analysis showed that high fasting plasma glucose (FPG), decreased fasting insulin level (FINS), and high triglyceride (TG) were independent risk factors of β cell dysfunction in newly diagnosed T2DM. Therefore, the management of dyslipidemia, together with glucose control, may be beneficial for T2DM with hyperlipidemia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.