ArticleBioMed research international2014
The molecular mechanisms of Tanshinone IIA on the apoptosis and arrest of human esophageal carcinoma cells.
Article in BioMed research international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 22 citations in OpenAlex.
- Construction and Screening of Fractional Library ofJournal of oncology · 2022Article
- Function of p21 and its therapeutic effects in esophageal cancer.Oncology letters · 2021Review
- An overview of the anti-cancer actions of Tanshinones, derived fromExploration of targeted anti-tumor therapy · 2020Review
- The anticancer mechanism investigation of Tanshinone IIBMC systems biology · 2018Article
- Tan IIA inhibits H1299 cell viability through the MDM4‑IAP3 signaling pathway.Molecular medicine reports · 2018Article
- Synergistic antitumor effects of tanshinone IIA and sorafenib or its derivative SC-1 in hepatocellular carcinoma cells.OncoTargets and therapy · 2018Article
- Mechanism of Oxymatrine-induced Human Esophageal Cancer Cell Apoptosis by the Endoplasmic Reticulum Stress Pathway.Open life sciences · 2018Article
- Tanshinone IIA Inhibits Epithelial-Mesenchymal Transition in Bladder Cancer Cells via Modulation of STAT3-CCL2 Signaling.International journal of molecular sciences · 2017Article
- Influence of Tanshinone IIA on apoptosis of human esophageal carcinoma Eca-109 cells and its molecular mechanism.Thoracic cancer · 2017Article
- Tanshinone IIA enhances chemosensitivity of colon cancer cells by suppressing nuclear factor-κB.Experimental and therapeutic medicine · 2016Article
- A promising "TRAIL" of tanshinones for cancer therapy.BioMedicine · 2015Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo explore the possible mechanisms of Tanshinone IIA (TanIIA) on esophageal carcinoma cell lines.
methodsTwo human esophageal carcinoma cell lines (EC-1 cells and ECa-109 cells) were treated with different concentrations of TanIIA. Cell proliferation was measured by CCK-8, colony-forming efficiency was calculated, cell cycle and apoptosis were measured, and changes in cell cycle- and apoptosis-related gene expression were measured by Western blotting.
resultsThe CCK-8 and colony formation assay indicated that TanIIA inhibited the cell proliferation of human esophageal cancer cells (IC50 below 1 μg/mL) at 48 h. Hoechst 33258 and flow cytometry showed that TanIIA induced apoptosis in both esophageal cancer cell lines. Flow cytometry showed that TanIIA arrested cell cycle in S phase and G2/M phase. Western blotting analysis showed that Akt1 and its phosphorylation were inhibited, the Bax/Bcl-2 ratio increased, and both caspase-9 and caspase-3 were activated after treatment with 1.3 μg/mL TanIIA at 48 h. Meanwhile, p53 and p21 protein levels increased, whereas cyclin B1, CDC2, and CDC2 phosphorylation were inhibited.
conclusionTanIIA inhibits the growth of esophageal cancer cells and induces apoptosis in a time-dependent and concentration-dependent manner, possibly by affecting cell cycle- and apoptosis-related signaling pathways.
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