ArticleWorld journal of clinical oncology2014
Prognostic value of preoperative serum tumor markers in gastric cancer.
Article in World journal of clinical oncology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Clinicopathologic and Prognostic Value of Serum Carbohydrate Antigen 19-9 in Gastric Cancer: A Meta-Analysis.Disease markers · 2015Pooled it
- Analysis and Exploration of the Relationship Between the Status of Serum Tumor Markers and Clinicopathological Features and Curative Effects in Gastric Cancer and Gastroesophageal Junction Tumor.OncoTargets and therapy · 2025Article
- Perioperative lymphocyte-to-monocyte ratio changes plus CA199 in predicting the prognosis of patients with gastric cancer.Journal of gastrointestinal oncology · 2022Article
- The Number of Positive Tumor Markers (NPTM) Achieves Higher Value in the Prognosis Prediction of Gastric Cancer.Disease markers · 2022Article
- Combination of tumor markers predicts progression and pathological response in patients with locally advanced gastric cancer after neoadjuvant chemotherapy treatment.BMC gastroenterology · 2021Article
- Clinical Value of Combined Detection of Serum sTim-3 and Pepsinogen for Gastric Cancer Diagnosis.Cancer management and research · 2021Article
- Using the preoperative prognostic nutritional index as a predictive factor for non-cancer-related death in post-curative resection gastric cancer patients: a retrospective cohort study.BMC gastroenterology · 2020Article
- The clinicopathological features and prognosis of serum AFP positive gastric cancer: a report of 16 cases.International journal of clinical and experimental pathology · 2020Article
- Prognostic Value of Changes in Preoperative and Postoperative Serum CA19-9 Levels in Gastric Cancer.Frontiers in oncology · 2020Article
- Prognostic value of the fibrinogen-to-platelet ratio as an inflammatory and coagulative index in patients with gastric cancer.Surgery today · 2019Article
- Single-step and ultrasensitive detection of carcinoembryonic antigen based on an aptamer transduction-mediated exonuclease III-assisted dual-amplification strategy.RSC advances · 2018Article
- An Alternative Method for Screening Gastric Cancer Based on Serum Levels of CEA, CA19-9, and CA72-4.Journal of gastrointestinal cancer · 2018Article
- Prognostic significance of pretreatment serum carcinoembryonic antigen levels in gastric cancer with pathological lymph node-negative: A large sample single-center retrospective study.World journal of gastroenterology · 2017Article
- Nomograms for predicting the prognostic value of serological tumor biomarkers in colorectal cancer patients after radical resection.Scientific reports · 2017Article
- The characteristics of the serum carcinoembryonic antigen and carbohydrate antigen 19-9 levels in gastric cancer cases.Surgery today · 2017Article
- Clinical significance and diagnostic value of serum CEA, CA19-9 and CA72-4 in patients with gastric cancer.Oncotarget · 2016Article
- Usefulness of Preoperative Plasma Fibrinogen Versus Other Prognostic Markers for Predicting Gastric Cancer Recurrence.World journal of surgery · 2016Article
- Prognostic significance of preoperative serum CA125, CA19-9 and CEA in gastric carcinoma.Oncotarget · 2016Article
- Differences and correlation of serum CEA, CA19-9 and CA72-4 in gastric cancer.Molecular and clinical oncology · 2016Article
- Prognostic value of neutrophil to lymphocyte ratio for gastric cancer.Annals of translational medicine · 2015Article
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8 authors.
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Abstract
aimTo evaluate the prognostic value of preoperative carcinoembryonic antigen (CEA), carbohydrate antigen (CA)19-9, and CA50 in patients undergoing D2 resection.
methodsWe evaluated 363 patients with gastric cancer who underwent gastrectomy at our hospital from January 2006 to December 2009. Blood samples were obtained from each patient within 1 wk before surgery. The cut-off values for serum CEA, CA19-9, and CA50 were 5 ng/mL, 37 U/mL, and 20 U/mL, respectively. The correlation between preoperative tumor marker levels and prognosis was studied by means of univariate and multivariate analyses.
resultsThe preoperative serum positive rates of CEA, CA19-9 and CA50 were 24.0%, 18.9% and 24.5%, respectively. The positivity rate of serum CEA was significantly correlated with age (P < 0.001), sex (P = 0.022), tumor size (P = 0.007) and depth of invasion (P = 0.018); CA19-9 with tumor size (P = 0.042) and lymph node metastasis (P < 0.001); and CA50 only with lymph node metastasis (P = 0.001). In multivariate analysis, tumor size, T category, N category, vascular or neural invasion, and adjuvant chemotherapy were independent prognostic factors for overall survival. CA19-9 had an independent prognostic significance in patients without adjuvant chemotherapy (P = 0.027).
conclusionPreoperative serum CEA, CA19-9 and CA50 are prognostic in patients with gastric cancer. Only CA19-9 is an independent prognostic factor after surgery without adjuvant chemotherapy.
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