Evidence map›Paper›PMID 24829793›Full record

ArticleTranslational neuroscience2013

REGION-SPECIFIC NEURON AND SYNAPSE LOSS IN THE HIPPOCAMPUS OF APP

Ivona Brasnjevic, Roy Lardenoije, Christoph Schmitz, Nicolien Van Der Kolk, Dara L Dickstein, Hisaaki Takahashi, Patrick R Hof, Harry W M Steinbusch, Bart P F Rutten

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Design-Based Stereology for Evaluation of Histological Parameters.Journal of molecular neuroscience : MN · 2017
    Article
  3. The epigenetics of aging and neurodegeneration.Progress in neurobiology · 2015
    Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 4 countries.

Ivona BrasnjevicDepartment of Psychiatry and Neuropsychology, Maastricht University, 6200 MD Maastricht, The Netherlands ; European Graduate School of Neuroscience (EURON), 6200 MD Maastricht, The Netherlands.
Roy LardenoijeDepartment of Psychiatry and Neuropsychology, Maastricht University, 6200 MD Maastricht, The Netherlands.
Christoph SchmitzDepartment of Anatomy II, Institute of Anatomy, Ludwig-Maximilians-University, 80336 Munich, Germany.
Nicolien Van Der KolkDepartment of Psychiatry and Neuropsychology, Maastricht University, 6200 MD Maastricht, The Netherlands ; European Graduate School of Neuroscience (EURON), 6200 MD Maastricht, The Netherlands.
Dara L DicksteinFishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Hisaaki TakahashiDepartment of Molecular and Cellular Physiology, Graduate School of Medicine, Ehime University, 791-0295 Ehime, Japan.
Patrick R HofFishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Harry W M SteinbuschDepartment of Psychiatry and Neuropsychology, Maastricht University, 6200 MD Maastricht, The Netherlands ; European Graduate School of Neuroscience (EURON), 6200 MD Maastricht, The Netherlands.
Bart P F RuttenDepartment of Psychiatry and Neuropsychology, Maastricht University, 6200 MD Maastricht, The Netherlands ; European Graduate School of Neuroscience (EURON), 6200 MD Maastricht, The Netherlands.
Maastricht University · NLAllen Institute for Brain Science · USEuropean Graduate School of Neuroscience · NLEhime University · JPLudwig-Maximilians-Universität München · DE

Funding

VESICULAR LOCALIZATION AND FUNCTION OF PRESENILIN 1 FRAGMENTP50AG005138 · NIA · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI SCHIMMING, CORBETT · 1985 to 2019
$37.9M
NIA NIH HHS P50 AG005138
6 · The paper itself

Abstract

Transgenic mouse models with knock-in (KI) expression of human mutant amyloid precursor protein (APP) and/or human presenilin 1 (PS1) may be helpful to elucidate the cellular consequences of APP and PS1 misprocessing in the aging brain. Age-related alterations in total numbers of neurons and in numbers of synaptophysin-immunoreactive presynaptic boutons (SIPB), as well as the amyloid plaque load were analyzed in the hippocampal dentate gyrus (DG), CA3, and CA1-2 of 2- and 10-month-old APP

Indexed as

Alzheimer’s diseaseAmyloid precursor proteinHippocampusImage analysisNeuron lossPresenilin-1StereologySynapse loss

Identifiers

PMID24829793
PMCPMC4018205
OpenAlexW2073344985

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.